Zinc Deficiency Leads to Lipid Changes inDrosophilaBrain Similar to Cognitive-Impairing Drugs: An Imaging Mass Spectrometry Study
Artikel i vetenskaplig tidskrift, 2020

Several diseases and disorders have been suggested to be associated with zinc deficiency, especially learning and memory impairment. To have better understanding about the connection between lipid changes and cognitive impairments, we investigated the effects of a zinc-chelated diet on certain brain lipids ofDrosophila melanogasterby using time-of-flight secondary ion mass spectrometry (ToF-SIMS). The data revealed that there are increases in the levels of phosphatidylcholine and phosphatidylinositol in the central brains of the zinc-deficient flies compared to the control flies. In contrast, the abundance of phosphatidylethanolamine in the brains of the zinc-deficient flies is lower. These data are consistent with that of cognitive-diminishing drugs, thus providing insight into the biological and molecular effects of zinc deficiency on the major brain lipids and opening a new treatment target for cognitive deficit in zinc deficiency.

lipid changes

Drosophila melanogaster

mass spectrometry imaging

cognition

zinc deficiency

Författare

Thuy Mai Hoang Philipsen

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Fysikalisk kemi

Chaoyi Gu

Göteborgs universitet

Andrew G. Ewing

Göteborgs universitet

ChemBioChem

1439-4227 (ISSN) 1439-7633 (eISSN)

Vol. In Press

Ämneskategorier

Farmaceutisk vetenskap

Neurovetenskaper

Neurologi

DOI

10.1002/cbic.202000197

PubMed

32402134

Mer information

Senast uppdaterat

2020-08-25