Validation of the Retinopathy of Prematurity Activity Scale (ROP-ActS) using retrospective clinical data
Artikel i vetenskaplig tidskrift, 2020

Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation. Purpose: The International Neonatal Consortium recently published a proposed retinopathy of prematurity (ROP) activity scale intended for use in clinical trials after validation. The aim of this study was to validate the ROP activity scale (ROP-ActS) in a ROP screened cohort with protocol based collected data by evaluating the ability of the ROP-Act scores to predict ROP treatment. In addition, we aimed to evaluate the scale’s sensitivity characteristic of disease severity by studying association with gestational age (GA) in comparison with conventionally used ROP stage and zone. Methods: A cohort of 535 preterm infants with 3324 ROP examinations with an end-point of ROP treatment or end of screening in Gothenburg, Sweden, was included. Median GA was 28.1 weeks, 47.5% were girls, and 74 (13.8%) infants were treated for ROP. The validation was performed by estimating probabilities for ROP treatment, and by applying logistic and linear regression. Results: The original ROP-ActS was overall well-ordered with respect to ability to predict ROP treatment but could be improved by re-ordering score 3 (zone II stage 1) and 5 (zone III stage 3) based on our clinical cohort data. The modified ROP-ActS was superior to ROP stage and zone in the prediction analysis of ROP treatment. Modified ROP-ActS was more strongly related to GA than currently used ROP stage, but not zone. Conclusion: In the studied cohort, the modified ROP-ActS could better predict ROP treatment compared to ROP stage and zone. Retinopathy of Prematurity Activity Scale (ROP-ActS) had a superior sensitivity characteristic studied through association to GA than conventionally used ROP stage.

ROP-ActS

retinopathy of prematurity

ROP activity scale

ROP stage

ROP zone

Författare

A. Pivodic

Göteborgs universitet

Statistiska Konsultgruppen

Staffan Nilsson

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

Göteborgs universitet

Andreas Stahl

University Medical Center Greifswald

Lois E.H. Smith

Harvard Medical School

Ann Hellström

Göteborgs universitet

Acta Ophthalmologica

1755-375X (ISSN) 1755-3768 (eISSN)

Vol. In Press

Ämneskategorier

Pediatrik

Urologi och njurmedicin

Oftalmologi

DOI

10.1111/aos.14532

PubMed

32592272

Mer information

Senast uppdaterat

2020-08-20