Plasma metabolites mediate the association of coarse grain intake with blood pressure in hypertension-free adults
Artikel i vetenskaplig tidskrift, 2020

Increased intake of whole/coarse grains was associated with improved blood pressure control, but concurrent metabolism alterations are less clear. We sought to identify metabolomic profiles of blood pressure, and to explore their mediation effects on the coarse grain intake-blood pressure association among young adults free of hypertension. Methods and results: Plasma metabolome of 86 participants from the Carbohydrate Alternatives and Metabolic Phenotypes study was characterized by untargeted lipidomics and metabolomics using liquid chromatography–high-resolution mass spectrometry. We identified 24 and 117 metabolites associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP), respectively, using random forest modeling and partial correlation analysis. Moreover, metabolite panels for highly specific prediction of blood pressure (8 metabolites for SBP and 11 metabolites for DBP) were determined using ten-fold cross-validated ridge regression (R2 ≥ 0.70). We also observed an inverse association between metabolite panel of SBP (β ± SE = −0.02 ± 0.01, P = 0.04) or DBP (β ± SE = −0.03 ± 0.01, P = 0.02) and coarse grain intake. Furthermore, we observed significant mediating effects of metabolites, in particular, sphingolipid ceramides, on the association between coarse grain exposure and blood pressure using both bias-corrected bootstrap tests and high-dimensional mediation analysis adapted for large-scale and high-throughput omics data. Conclusions: We identified metabolomic profiles specifically associated with blood pressure in young Chinese adults without diagnosed hypertension. The inverse association between coarse grain intake and blood pressure may be mediated by sphingolipid metabolites.

Blood pressure

Coarse grain





Xin Liu

School of Basic Medical Sciences

Lin Shi

Shaanxi Normal University

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Xiaoshuang Dai

BGI Institute of Applied Agriculture

Huangtao Chen

School of Basic Medical Sciences

Chenglin Zhang

School of Basic Medical Sciences

Pei Wang

School of Basic Medical Sciences

Qian Wu

School of Basic Medical Sciences

Lingxia Zeng

School of Basic Medical Sciences

Hong Yan

Xi'an Jiaotong University

School of Basic Medical Sciences

Nutrition, Metabolism and Cardiovascular Diseases

0939-4753 (ISSN) 1590-3729 (eISSN)

Vol. 30 9 1512-1519


Annan klinisk medicin





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