On-Command Regulation of Kinase Activity using Photonic Stimuli
Reviewartikel, 2019

The underlying role that many kinases play in complex cellular pathways as well as disease remains unclear. To better understand the role that kinases play in both health and disease states, the use of light as an external stimulus to modulate kinase activity with high spatiotemporal resolution has gained increasing interest over the years. Herein we highlight the progress made towards the development of light-responsive kinase enzymes and small molecule inhibitors. In these examples, photolabile caging groups and photoswitchable entities have been utilised to modulate either kinase activation or inhibition in a light-controlled manner.

photopharmacology

chemical biology

kinase inhibition

photocaging

photoswitching

Författare

Cassandra L. Fleming

Göteborgs universitet

Morten Grotli

Göteborgs universitet

Joakim Andreasson

Chalmers, Kemi och kemiteknik, Kemi och biokemi

CHEMPHOTOCHEM

2367-0932 (ISSN)

Vol. 3 6 318-326

Styrkeområden

Nanovetenskap och nanoteknik (SO 2010-2017, EI 2018-)

Ämneskategorier

Annan medicinsk grundvetenskap

Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Läkemedelskemi

DOI

10.1002/cptc.201800253

Mer information

Senast uppdaterat

2020-08-31