The relation of 25-hydroxy vitamin D concentrations to liver histopathology, seasonality and baseline characteristics in chronic hepatitis C virus genotype 2 or 3 infection
Artikel i vetenskaplig tidskrift, 2020

BACKGROUND AND OBJECTIVES: The hydroxylation to 25-hydroxy vitamin D (25(OH)D) occurs in the liver and the impact of liver disease on vitamin D is unclear. This study evaluated the relationship between vitamin D concentrations and hepatic histopathology, seasonality and patient characteristics in well-characterized patients having undergone a liver biopsy. METHOD: 25(OH)D was measured post-hoc in pre-treatment serum from 331 North European patients with chronic HCV genotype 2 or 3 infection (NORDynamIC study). Liver biopsies were scored for fibrosis and inflammation according to the Ishak protocol, and graded for steatosis. Non-invasive markers of hepatic fibrosis as well as baseline viral and host characteristics, including genetic polymorphisms rs2228570, rs7975232, and rs10877012 were also evaluated. RESULTS: Mean 25(OH)D concentration was 59 ±23 nmol/L, with 41% having values <50 nmol/L and 6% were <30 nmol/L. 25(OH)D correlated with fibrosis (r = -0.10, p ≤0.05) in univariate but not in multivariate analyses. No association was observed between 25(OH)D and hepatic inflammation, but with steatosis in HCV genotype 2 infected patients. None of the genetic polymorphisms impacted on 25(OH)D levels or fibrosis. 25(OH)D levels were significantly inversely correlated to BMI (r = -0.19, p = 0.001), and was also associated with season and non-Caucasian ethnicity. CONCLUSION: Fibrosis was not independently associated with 25(OH)D concentration and no association was seen with hepatic inflammation, but HCV genotype 2 infected patients with moderate-to-severe steatosis had lower 25(OH)D levels compared to those without steatosis. A high percentage had potential risk of 25(OH)D deficiency, and BMI, seasonality and ethnicity were independently associated with 25(OH)D as previously reported.

Författare

Jesper Waldenström

Göteborgs universitet

Sahlgrenska universitetssjukhuset

Kristina Nyström

Göteborgs universitet

Sahlgrenska universitetssjukhuset

Staffan Nilsson

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

Gunnar Norkrans

Göteborgs universitet

Magdalena Ydreborg

Sahlgrenska universitetssjukhuset

Göteborgs universitet

Nina Langeland

Universitetet i Bergen

Helse Bergen Haukeland University Hospital

Kristine Mørch

Universitetet i Bergen

Helse Bergen Haukeland University Hospital

Johan Westin

Sahlgrenska universitetssjukhuset

Göteborgs universitet

Martin Lagging

Göteborgs universitet

Sahlgrenska universitetssjukhuset

PLoS ONE

1932-6203 (ISSN)

Vol. 15 8 e0237840

Ämneskategorier

Gastroenterologi

Urologi och njurmedicin

Reumatologi och inflammation

DOI

10.1371/journal.pone.0237840

PubMed

32822420

Mer information

Senast uppdaterat

2020-09-21