Development and Evaluation of Drug Loaded Regenerated Bacterial Cellulose-Based Matrices as a Potential Dosage Form
Artikel i vetenskaplig tidskrift, 2020

Bacterial cellulose (BC) is a highly pure form of cellulose and possesses superior physico-mechanical properties with wide range of applications. These properties of BC can further be improved by various modifications, including its regeneration from the BC solution. In the current research work, regenerated BC (R-BC) matrices were prepared using N-methyl-morpholine-oxide (NMMO; 50% w/w solution in water) and loaded with model drugs, i.e., famotidine or tizanidine. The characterization of drug loaded regenerated BC (R-BC-drug) matrices was carried out using Fourier transform infrared spectroscopy (FTIR), x-ray diffraction (XRD) analysis, scanning electron microscopy (SEM) and thermogravimetric analysis (TGA), which revealed the stability of matrices and successful drug loading. Results of dissolution studies showed immediate (i.e., >90%) drug release in 30 min. The drugs release data was found to best fit into first order kinetics model having R2 values >0.99 for all the formulations. These results indicated that regenerated BC-based matrices had the ability to be used for delivery of orally administered drugs.

bacterial cellulose

drug delivery

regeneration

famotidine

tizanidine

Författare

Munair Badshah

COMSATS University Islamabad

Hanif Ullah

COMSATS University Islamabad

Feng He

Huanggang Normal University

Fazli Wahid

Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology

Umar Farooq

COMSATS University Islamabad

Mattias Andersson

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Polymerteknologi

Taous Khan

COMSATS University Islamabad

Frontiers in Bioengineering and Biotechnology

2296-4185 (ISSN)

Vol. 8 579404

Ämneskategorier

Polymerkemi

Farmaceutisk vetenskap

DOI

10.3389/fbioe.2020.579404

Mer information

Senast uppdaterat

2021-01-05