Higher plasma drug levels in elderly people living with HIV treated with darunavir
Artikel i vetenskaplig tidskrift, 2021

Background The proportion of elderly people living with HIV-1 (PLHIV) is rising. In older patients, comorbidities and concomitant medications are more frequent, increasing the risk of potential drug-drug interactions (PDDIs). Data on the pharmacokinetics of ART in individuals aged < 65 years of age are scarce. We compared plasma drug levels of ART, PDDIs, and sideeffects in PLHIV aged < 65 years of age, with controls > 49 years of age. Methods Patients < 65 years of age and controls > 49 years of age, all of whom were on stable treatment with atazanavir (ATV), darunavir (DRV), or efavirenz (EFV) were included cross-sectionally. Plasma drug levels of ART were analyzed, comorbidities, concomitant medication, adherence, and side-effects recorded, and PDDIs analyzed using drug interactions databases. Results Between 2013 and 2015, we included 100 individuals ≥ 65 years of age (study group) and 99 controls (<49 years of age). Steady-state DRV concentrations were significantly higher in the study group than in the control group (p = 0.047). In the ATV group there was a trend towards a significant difference (p = 0.056). No significant differences were found in the EFV arm. The DRV arm had a higher frequency of reported side-effects than the ATV and EFV arms in the study group (36.7% vs. 0% and 23.8% respectively (p = 0.014), with significant differences between DRV vs. ATV, and EFV vs. ATV). Conclusions Higher steady-state plasma levels of DRV and ATV (but not EFV) were found in PLHIV aged < 65 years of age, compared to controls >49 years of age.

Författare

Erika Tyrberg

Göteborgs universitet

Sahlgrenska universitetssjukhuset

Arvid Edén

Sahlgrenska universitetssjukhuset

Göteborgs universitet

Jaran Eriksen

Södersjukhuset

Karolinska Institutet

Staffan Nilsson

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

Carl Johan Treutiger

Södersjukhuset

Anders Thalme

Karolinska universitetssjukhuset

Åsa Mellgren

Södersjukhuset

Göteborgs universitet

Magnus Gisslen

Göteborgs universitet

Sahlgrenska universitetssjukhuset

L. M. Andersson

Sahlgrenska universitetssjukhuset

Göteborgs universitet

PLoS ONE

1932-6203 (ISSN)

Vol. 16 2 February e0246171

Ämneskategorier

Geriatrik

Samhällsfarmaci och klinisk farmaci

Gerontologi, medicinsk/hälsovetenskaplig inriktning

DOI

10.1371/journal.pone.0246171

PubMed

33539440

Mer information

Senast uppdaterat

2021-02-25