Evaluation of the Forsvall biopsy needle in an ex vivo model of transrectal prostate biopsy - a novel needle design with the objective to reduce the risk of post-biopsy infection
Artikel i vetenskaplig tidskrift, 2021

Background Transrectal prostate biopsy (TRbx) transfers colonic bacteria into prostatic tissue, potentially causing infectious complications, including sepsis. Our objective was to determine whether biopsy needle shape, surface properties and sampling mechanism affect the number of bacteria transferred through the colon wall, and evaluate a novel needle with improved properties. Methods The standard Tru-Cut biopsy needle used today was evaluated for mechanisms of bacterial transfer in a pilot study. A novel Tru-Cut needle (Forsvall needle prototype) was developed. TRbx was simulated using human colons ex-vivo. Four subtypes of the prototype needle were compared with a standard Tru-Cut needle (BARD 18 G). Prototype and standard needles were used to puncture 4 different colon specimens in 10 randomized sites per colon. Needles were submerged into culture media to capture translocated bacteria. The media was cultured on blood agar and then the total amount of transferred bacteria was calculated for each needle. The primary outcome measure was the percent reduction of bacteria translocated by the prototype needles relative to the standard needle. Secondary outcome measures were the effects of tip design and coating on the percent reduction of translocated bacteria. Results Prototype needles reduced the number of translocated bacteria by, on average, 96.0% (95% confidence interval 93.0-97.7%; p < 0.001) relative to the standard needle. This percent reduction was not significantly affected by prototype needle tip style or surface coating. Conclusions The Forsvall needle significantly reduces colonic bacterial translocation, suggesting that it could reduce infectious complications in prostate biopsy. A clinical trial has been initiated.

prostate biopsy

sepsis

tru-cut biopsy needle

infection

Biopsy needle

trans rectal prostate biopsy

Författare

Andreas Forsvall

Helsingborgs Lasarett

Lunds universitet

Jane Fisher

Lunds universitet

Jose Francisco Pereira Cardoso

Lunds universitet

Magnus Wagenius

Lunds universitet

Helsingborgs Lasarett

Jonas Tverring

Helsingborgs Lasarett

Lunds universitet

Bo Nilson

Lunds universitet

Region Skåne

Andreas Dahlin

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Andreas Dahlin Group

Ola Bratt

Göteborgs universitet

Adam Linder

Lunds universitet

Tirthankar Mohanty

Lunds universitet

Scandinavian Journal of Urology

2168-1805 (ISSN) 2168-1813 (eISSN)

Vol. In Press

Ämneskategorier

Medicinsk laboratorie- och mätteknik

Biomaterial

Biomaterialvetenskap

DOI

10.1080/21681805.2021.1921023

PubMed

33999764

Mer information

Senast uppdaterat

2021-06-02