Analysis of 6 genetic loci for disease susceptibility in psoriatic arthritis.
Artikel i vetenskaplig tidskrift, 2004
OBJECTIVE: To analyze the association of several autoimmune disease susceptibility loci in a population of patients with psoriasis and defined joint disease from northern Sweden. METHOD: One hundred twenty patients with psoriasis and defined joint disease were examined clinically, radiologically, and with laboratory-based analyses. Disease classification was based on peripheral and/or axial engagement. The tumor necrosis factor (TNF) locus, 1q21 (PSORS4), 3q21 (PSORS5), 8q24, 16q21, and the CTLA4 gene were analyzed using a total of 38 microsatellite markers and 2 single nucleotide polymorphisms (SNP). Ninety-four controls with the same ethnic background as the patients were randomly selected from the same region of Sweden. RESULTS: An association was found with one of the markers in the TNFB locus within the HLA region (p = 0.012, pc = 0.024). Three markers at the PSORS4 locus on chromosome 1q21 and 2 markers at the 8q24 locus showed nominal p values of < 0.05. After applying the Bonferroni correction for multiple analyses these markers did not reach significance. No other marker showed significant association. In a subgroup of the patients, possible linkage disequilibrium between the TNFB123 and HLA-B antigens, B17, B27, B37, B44, and B62 was analyzed. A significant linkage (p = 0.0001) was found. CONCLUSION: We identified an association between psoriatic arthritis and one of the microsatellite markers within the TNFB locus at the HLA region on chromosome 6. Linkage disequilibrium between TNFB123 and certain HLA-B antigens was found.
genetics
pathology
genetics
Adult
genetics
Single Nucleotide
Chromosomes
Microsatellite Repeats
Humans
Human
Middle Aged
Linkage Disequilibrium
genetics
Pair 6
Polymorphism
Lymphotoxin-alpha
Genetic Predisposition to Disease
Arthritis
Genetic Markers
Psoriatic
immunology
Autoimmunity
Författare
Gerd-Marie Alenius
Camilla Friberg
Göteborgs universitet
Staffan Nilsson
Göteborgs universitet
Chalmers, Institutionen för matematisk statistik
Jan Wahlström
Göteborgs universitet
Solbritt Dahlqvist Rantapää
Lena Samuelsson
Göteborgs universitet
Journal of Rheumatology
0315-162X (ISSN) 1499-2752 (eISSN)
Vol. 31 11 2230-5Ämneskategorier
MEDICIN OCH HÄLSOVETENSKAP