Radiobiological evaluation of combined gamma knife radiosurgery and hyperthermia for pediatric neuro-oncology
Artikel i vetenskaplig tidskrift, 2021

Combining radiotherapy (RT) with hyperthermia (HT) has been proven effective in the treatment of a wide range of tumours, but the combination of externally delivered, focused heat and stereotactic radiosurgery has never been investigated. We explore the potential of such treatment enhancement via radiobiological modelling, specifically via the linear-quadratic (LQ) model adapted to thermoradiotherapy through modulating the radiosensitivity of temperature-dependent parame-ters. We extend this well-established model by incorporating oxygenation effects. To illustrate the methodology, we present a clinically relevant application in pediatric oncology, which is novel in two ways. First, it deals with medulloblastoma, the most common malignant brain tumour in children, a type of brain tumour not previously reported in the literature of thermoradiotherapy studies. Second, it makes use of the Gamma Knife for the radiotherapy part, thereby being the first of its kind in this context. Quantitative metrics like the biologically effective dose (BED) and the tumour control probability (TCP) are used to assess the efficacy of the combined plan.

Biological modelling


Stereotactic radiotherapy


CNS tumors

LQ model


Morteza Ghaderi Aram

Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik

Massimiliano Zanoli

Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik

Håkan Nordström


Iuliana Toma-Dasu

Karolinska universitetssjukhuset

Stockholms universitet

K. Blomgren

Karolinska universitetssjukhuset

Karolinska Institutet

Hana Dobsicek Trefna

Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik


20726694 (eISSN)

Vol. 13 13 3277


Farmaceutisk vetenskap

Sannolikhetsteori och statistik

Radiologi och bildbehandling





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