Chemical modification of glycosaminoglycan polysaccharides
Reviewartikel, 2021

The linear anionic class of polysaccharides, glycosaminoglycans (GAGs), are critical throughout the animal kingdom for developmental processes and the maintenance of healthy tis-sues. They are also of interest as a means of influencing biochemical processes. One member of the GAG family, heparin, is exploited globally as a major anticoagulant pharmaceutical and there is a growing interest in the potential of other GAGs for diverse applications ranging from skin care to the treatment of neurodegenerative conditions, and from the treatment and prevention of microbial infection to biotechnology. To realize the potential of GAGs, however, it is necessary to develop effective tools that are able to exploit the chemical manipulations to which GAGs are susceptible. Here, the current knowledge concerning the chemical modification of GAGs, one of the principal approaches for the study of the structure-function relationships in these molecules, is reviewed. Some additional methods that were applied successfully to the analysis and/or processing of other carbohydrates, but which could be suitable in GAG chemistry, are also discussed.

Chemical modification

Glycosaminoglycans

Sulfation

Polysaccharides

Författare

Lais C.G.F. Palhares

Universidade Federal do Rio Grande do Norte

James A. London

University of Liverpool

Aleksandra Maria Kozlowski

Chalmers, Kemi och kemiteknik, Kemiteknik, Skogsindustriell kemiteknik

Emiliano Esposito

Istituto Ronzoni

Suely F. Chavante

Universidade Federal do Rio Grande do Norte

Minghong Ni

Istituto Ronzoni

Edwin A. Yates

University of Liverpool

Molecules

1420-3049 (ISSN)

Vol. 26 17 5211

Ämneskategorier

Kemiska processer

Bioprocessteknik

Tillförlitlighets- och kvalitetsteknik

DOI

10.3390/molecules26175211

PubMed

34500644

Mer information

Senast uppdaterat

2021-09-13