Ultrastructural changes of bovine tooth surfaces under erosion in presence of biomimetic
Artikel i vetenskaplig tidskrift, 2021

Enamel and dentin are susceptible to acids from food sources leading to dental erosion, a global problem affecting millions of individuals. Particulate hydroxyapatite (HAP) on the tooth surface can influence the effects of acid attacks. Standardized bovine enamel and dentin samples with artificial saliva are used in an in vitro cyclic demineralization-remineralization protocol to analyze the structural changes experienced by tooth surfaces using high-resolution scanning electron microscopy and to evaluate the potential of a HAP-based oral care gel in the protection of teeth from erosive attacks. The interfaces between HAP particle and enamel HAP crystallites are investigated using focused ion beam preparation and transmission electron microscopy. The results show that erosion with phosphoric acid severely affects enamel crystallites and dentin tubules, while artificial saliva leads to remineralization effects. The HAP-gel forms a microscopic layer on both enamel and dentin surfaces. Upon acid exposure, this layer is sacrificed before the native tooth tissues are affected, leading to significantly lower degrees of demineralization compared to the controls. This demonstrates that the use of particulate HAP as a biomaterial in oral care formulations can help protect enamel and dentin surfaces from erosive attacks during meals using a simple and effective protection principle.


biomimetic materials





Kathia Fabritius-Vilpoux

Max Planck Inst Eisenforsch GmbH

Joachim Enax

Dr Kurt Wolff GmbH & Co KG

David Mayweg

Chalmers, Fysik, Mikrostrukturfysik

Frederic Meyer

Dr Kurt Wolff GmbH & Co KG

Michael Herbig

Max Planck Inst Eisenforsch GmbH

Dierk Raabe

Max Planck Inst Eisenforsch GmbH

Helge-Otto Fabritius

Max Planck Inst Eisenforsch GmbH

Hamm Lippstadt Univ Appl Sci

Bioinspired, Biomimetic and Nanobiomaterials

2045-9858 (ISSN) 2045-9866 (eISSN)

Vol. 10 4 132-145



Annan kemi

Medicinska material och protesteknik



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