Deciphering the Potential Coding of Human Cytomegalovirus: New Predicted Transmembrane Proteome
Artikel i vetenskaplig tidskrift, 2022

CMV is a major cause of morbidity and mortality in immunocompromised individuals that will benefit from the availability of a vaccine. Despite the efforts made during the last decade, no CMV vaccine is available. An ideal CMV vaccine should elicit a broad immune response against multiple viral antigens including proteins involved in virus-cell interaction and entry. However, the therapeutic use of neutralizing antibodies targeting glycoproteins involved in viral entry achieved only partial protection against infection. In this scenario, a better understanding of the CMV prote-ome potentially involved in viral entry may provide novel candidates to include in new potential vaccine design. In this study, we aimed to explore the CMV genome to identify proteins with puta-tive transmembrane domains to identify new potential viral envelope proteins. We have performed in silico analysis using the genome sequences of nine different CMV strains to predict the trans-membrane domains of the encoded proteins. We have identified 77 proteins with transmembrane domains, 39 of which were present in all the strains and were highly conserved. Among the core proteins, 17 of them such as UL10, UL139 or US33A have no ascribed function and may be good candidates for further mechanistic studies.






Francisco J. Mancebo

Centro Nacional de Microbiologia

Marcos Parras Moltó

Igenomix Foundation

Göteborgs universitet

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

Estéfani García-Ríos

Universidad Internacional de Valencia

Centro Nacional de Microbiologia

Pilar Pérez-Romero

Centro Nacional de Microbiologia

International Journal of Molecular Sciences

16616596 (ISSN) 14220067 (eISSN)

Vol. 23 5 2768


Biokemi och molekylärbiologi

Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Mikrobiologi inom det medicinska området





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