Thyme Oil Nanoemulsion Enhanced Cellular Antioxidant and Suppressed Inflammation in Mice Challenged by Cadmium-Induced Oxidative Stress
Artikel i vetenskaplig tidskrift, 2022

Cadmium is a poisonous trace element which induces oxidative stress and pollutes the environment. Nanoemulsions are recognized as a new drug delivery system with enhanced therapeutic efficacy. In the present study, nanoemulsion of Thymus vulgaris essential oil was prepared and characterized. The effects of the essential oil on body weight gain, liver mineral content, histopathology, lipid peroxidation, antioxidant- and inflammatory-related gene expressions were also investigated in mice challenged by cadmium-induced oxidative stress. Characterization of nanoemulsion (e.g., polydispersity index, particle size, and ζ-potential) indicated a good stability degree of T. vulgaris essential oil. Phytochemical analysis by GC–MS also demonstrated T. vulgaris essential oil contained phenolic compounds i.e., thymol, p-cymene, ɣ-teripinene, carvacrol, caryophyllene and linalool. The treatment of mice with T. vulgaris essential oil significantly (p < 0.05) improved body weight changes, reduced cadmium deposition in the liver and decreased lipid peroxidation compared to control group. Also, the antioxidative potential was enhanced whereas inflammation in the tissues were suppressed. The GPx gene was up regulated whereas iNOS genes were significantly (p < 0.05) downregulated in kidney, liver and brain tissues. Our findings suggest T.vulgaris essential oil can be a promising protective agent against cadmium-induced oxidative stress.


Encapsulation, Body weight loss

Medicinal plant

Drug delivery


Heavy metals


Fatemeh Rahmani

Islamic Azad University, Mashhad Branch

Sajed Nabi

Islamic Azad University, Mashhad Branch

Reza Baratpour Idliki

Islamic Azad University, Mashhad Branch

Masoumeh Alimirzaei

Islamic Azad University, Mashhad Branch

Seyed Mohammad Adel Barkhordar

Islamic Azad University, Mashhad Branch

Negin Shafaei

Islamic Azad University, Mashhad Branch

Mohsen Zareian

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Ehsan Karimi

Islamic Azad University, Mashhad Branch

Ehsan Oskoueian

Waste and Biomass Valorization

1877-2641 (ISSN) 1877-265X (eISSN)

Vol. In Press



Farmakologi och toxikologi

Medicinsk bioteknik



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