Electrically Switchable Polymer Brushes for Protein Capture and Release in Biological Environments**
Artikel i vetenskaplig tidskrift, 2022

Interfaces functionalized with polymers are known for providing excellent resistance towards biomolecular adsorption and for their ability to bind high amounts of protein while preserving their structure. However, making an interface that switches between these two states has proven challenging and concepts to date rely on changes in the physiochemical environment, which is static in biological systems. Here we present the first interface that can be electrically switched between a high-capacity (>1 μg cm−2) multilayer protein binding state and a completely non-fouling state (no detectable adsorption). Switching is possible over multiple cycles without any regeneration. Importantly, switching works even when the interface is in direct contact with biological fluids and a buffered environment. The technology offers many applications such as zero fouling on demand, patterning or separation of proteins as well as controlled release of biologics in a physiological environment, showing high potential for future drug delivery in vivo.

Electrochemistry

Polymer Brushes

Proteins

Adsorption

Författare

Gustav Ferrand-Drake Del Castillo

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Andreas Dahlin Group

Maria Kyriakidou

Cardiff University

Zeynep Adali

Kunli Xiong

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Andreas Dahlin Group

Rebekah Hailes

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Andreas Dahlin Group

Andreas Dahlin

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Andreas Dahlin Group

Angewandte Chemie - International Edition

1433-7851 (ISSN) 1521-3773 (eISSN)

Vol. In Press

Ämneskategorier

Biokemi och molekylärbiologi

Biofysik

Bioinformatik och systembiologi

DOI

10.1002/anie.202115745

Mer information

Senast uppdaterat

2022-04-14