National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity
Artikel i vetenskaplig tidskrift, 2022
Aim: To describe survival and neonatal morbidities in infants born before 24 weeks of gestation during a 12-year period. Methods: Data were retrieved from national registries and validated in medical files of infants born before 24 weeks of gestation 2007–2018 in Sweden. Temporal changes were evaluated. Results: In 2007–2018, 282 live births were recorded at 22 weeks and 460 at 23 weeks of gestation. Survival to discharge from hospital of infants born alive at 22 and 23 weeks increased from 20% to 38% (p = 0.006) and from 45% to 67% (p < 0.001) respectively. Caesarean section increased from 12% to 22% (p = 0.038) for infants born at 22 weeks. Neonatal morbidity rates in infants alive at 40 weeks of postmenstrual age (n = 399) were unchanged except for an increase in necrotising enterocolitis from 0 to 33% (p = 0.017) in infants born at 22 weeks of gestation. Bronchopulmonary dysplasia was more common in boys than girls, 90% versus 82% (p = 0.044). The number of infants surviving to 40 weeks doubled over time. Conclusion: Increased survival of infants born before 24 weeks of gestation resulted in increasing numbers of very immature infants with severe neonatal morbidities likely to have a negative impact on long-term outcome.
proactive approach
extremely preterm
necrotising enterocolitis
neonatal morbidities
survival rates
Författare
Pia Lundgren
Göteborgs universitet
Eva Morsing
Lunds universitet
Anna Lena Hård
Göteborgs universitet
Alexander Rakow
Karolinska universitetssjukhuset
Lena Hellström-Westas
Uppsala universitet
Lena Jacobson
Göteborgs universitet
Karolinska universitetssjukhuset
Mats Johnson
Göteborgs universitet
Gerd Holmström
Uppsala universitet
Staffan Nilsson
Göteborgs universitet
Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik
Lois E.H. Smith
Harvard Medical School
Karin Sävman
Sahlgrenska universitetssjukhuset
Göteborgs universitet
Ann Hellström
Göteborgs universitet
Acta Paediatrica, International Journal of Paediatrics
0803-5253 (ISSN) 1651-2227 (eISSN)
Vol. 111 8 1515-1525Ämneskategorier
Pediatrik
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Reproduktionsmedicin och gynekologi
DOI
10.1111/apa.16354
PubMed
35395120