National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity
Artikel i vetenskaplig tidskrift, 2022

Aim: To describe survival and neonatal morbidities in infants born before 24 weeks of gestation during a 12-year period. Methods: Data were retrieved from national registries and validated in medical files of infants born before 24 weeks of gestation 2007–2018 in Sweden. Temporal changes were evaluated. Results: In 2007–2018, 282 live births were recorded at 22 weeks and 460 at 23 weeks of gestation. Survival to discharge from hospital of infants born alive at 22 and 23 weeks increased from 20% to 38% (p = 0.006) and from 45% to 67% (p < 0.001) respectively. Caesarean section increased from 12% to 22% (p = 0.038) for infants born at 22 weeks. Neonatal morbidity rates in infants alive at 40 weeks of postmenstrual age (n = 399) were unchanged except for an increase in necrotising enterocolitis from 0 to 33% (p = 0.017) in infants born at 22 weeks of gestation. Bronchopulmonary dysplasia was more common in boys than girls, 90% versus 82% (p = 0.044). The number of infants surviving to 40 weeks doubled over time. Conclusion: Increased survival of infants born before 24 weeks of gestation resulted in increasing numbers of very immature infants with severe neonatal morbidities likely to have a negative impact on long-term outcome.

proactive approach

extremely preterm

necrotising enterocolitis

neonatal morbidities

survival rates

Författare

Pia Lundgren

Göteborgs universitet

Eva Morsing

Lunds universitet

Anna Lena Hård

Göteborgs universitet

Alexander Rakow

Karolinska universitetssjukhuset

Lena Hellström-Westas

Uppsala universitet

Lena Jacobson

Göteborgs universitet

Karolinska universitetssjukhuset

Mats Johnson

Göteborgs universitet

Gerd Holmström

Uppsala universitet

Staffan Nilsson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

Lois E.H. Smith

Harvard Medical School

Karin Sävman

Sahlgrenska universitetssjukhuset

Göteborgs universitet

Ann Hellström

Göteborgs universitet

Acta Paediatrica, International Journal of Paediatrics

0803-5253 (ISSN) 1651-2227 (eISSN)

Vol. In Press

Ämneskategorier

Pediatrik

Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

Reproduktionsmedicin och gynekologi

DOI

10.1111/apa.16354

PubMed

35395120

Mer information

Senast uppdaterat

2022-04-25