A systematic review and meta-analysis on the effectiveness of web-based psychosocial interventions among patients with colorectal cancer
Reviewartikel, 2022

Aims: To synthesize the effectiveness of web-based psychosocial interventions on self-efficacy, anxiety, depression, quality of life (QoL), non-specific psychological and cancer-specific distress among patients with colorectal cancer (CRC). Design: A systematic review and meta-analysis. Data sources: Six databases (PubMed, PsycINFO, Embase, Scopus, CINAHL and CNKI) were searched from inception to December 2021. Review methods: Experimental/quasi-experimental studies involving patients with CRC for the improvement of aforementioned outcomes were included. Two reviewers screened and extracted the data, and assessed studies' methodological quality using risk of bias tools. Meta-analyses and narrative syntheses were performed. Results: Nineteen studies consisting of 1386 participants were identified. Cognitive-behavioural therapy delivered online was the most common trialled web-based psychosocial intervention. Meta-analyses revealed no positive effect for self-efficacy (standardized mean difference 0.93, 95% CI: 0.52 to 1.35, p <.01) and minimal benefit for QoL (mean difference [MD] 2.83, 95% CI: −0.31 to 5.98, p =.08) but significant positive effects for anxiety (MD −2.23, 95% CI: −3.31 to −1.14, p <.01) and depression (MD −2.84, 95% CI: −4.09 to −1.59, p <.01) among CRC survivors in the intervention group as compared with the control group. Narrative synthesis suggested possible benefits in reducing distress. Conclusion: Web-based psychosocial interventions are promising alternatives to conventional delivery methods in reducing patients' anxiety, depression and distress. However, evidence on self-efficacy and QoL remains inconsistent. More adequately powered, well-designed trials with targeted and theory-based interventions are required to ascertain findings. Impact: By highlighting the potential of web-based psychosocial interventions in reducing anxiety and depression among CRC survivors, this review has put forth beneficial information supporting the use and acceptance of web-based care delivery in light of COVID-19 restrictions and nationwide lockdowns. Meanwhile, the paucity of empirical support reflects the necessity of more extensive research to test and improve other health outcomes. PROSPERO registration number: CRD42021261396.


psychosocial intervention

systematic review

randomized controlled trial


colorectal cancer



Su Wei Wan

Yong Loo Lin School of Medicine

National University Health System

Yun Jia Devon Chng

Tan Tock Seng Hospital

Siew Hoon Lim

Singapore General Hospital

Choon Seng Chong

Yong Loo Lin School of Medicine

National University Hospital, Singapore

National University Health System

Minna Pikkarainen

Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik

OsloMet – storbyuniversitetet

Oulun Yliopisto

Hong Gu He

National University Health System

Yong Loo Lin School of Medicine

Journal of Advanced Nursing

0309-2402 (ISSN) 1365-2648 (eISSN)

Vol. In Press


Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi


Tillämpad psykologi



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