A Road Map toward Field-Effect Transistor Biosensor Technology for Early Stage Cancer Detection
Reviewartikel, 2022

Field effect transistor (FET)-based nanoelectronic biosensor devices provide a viable route for specific and sensitive detection of cancer biomarkers, which can be used for early stage cancer detection, monitoring the progress of the disease, and evaluating the effectiveness of therapies. On the road to implementation of FET-based devices in cancer diagnostics, several key issues need to be addressed: sensitivity, selectivity, operational conditions, anti-interference, reusability, reproducibility, disposability, large-scale production, and economic viability. To address these well-known issues, significant research efforts have been made recently. An overview of these efforts is provided here, highlighting the approaches and strategies presently engaged at each developmental stage, from the design and fabrication of devices to performance evaluation and data analysis. Specifically, this review discusses the multistep fabrication of FETs, choice of bioreceptors for relevant biomarkers, operational conditions, measurement configuration, and outlines strategies to improve the sensing performance and reach the level required for clinical applications. Finally, this review outlines the expected progress to the future generation of FET-based diagnostic devices and discusses their potential for detection of cancer biomarkers as well as biomarkers of other noncommunicable and communicable diseases.

sensitivity

biomarkers

cancer detection

FET biosensors

bioreceptors

Författare

Muthusankar Eswaran

Chalmers, Biologi och bioteknik, Systembiologi

Bavatharani Chokkiah

National Institute of Technology Puducherry

Santosh Pandit

Chalmers, Biologi och bioteknik, Systembiologi

Shadi Rahimi

Chalmers, Biologi och bioteknik, Systembiologi

Ragupathy Dhanusuraman

National Institute of Technology Puducherry

Mahaboobbatcha Aleem

City University of New York (CUNY)

Ivan Mijakovic

Chalmers, Biologi och bioteknik, Systembiologi

Small Methods

23669608 (eISSN)

Vol. 6 2200809

Cancerdetektion via CRISPR-baserad mutationsanalys i grafenchips

VINNOVA (2020-04733), 2021-05-14 -- 2023-05-14.

Ämneskategorier

Medicinsk laboratorie- och mätteknik

Biomedicinsk laboratorievetenskap/teknologi

Annan samhällsbyggnadsteknik

DOI

10.1002/smtd.202200809

PubMed

36068169

Mer information

Senast uppdaterat

2024-07-17