Domestication reprogrammed the budding yeast life cycle
Artikel i vetenskaplig tidskrift, 2022

Domestication of plants and animals is the foundation for feeding the world human population but can profoundly alter the biology of the domesticated species. Here we investigated the effect of domestication on one of our prime model organisms, the yeast Saccharomyces cerevisiae, at a species-wide level. We tracked the capacity for sexual and asexual reproduction and the chronological life span across a global collection of 1,011 genome-sequenced yeast isolates and found a remarkable dichotomy between domesticated and wild strains. Domestication had systematically enhanced fermentative and reduced respiratory asexual growth, altered the tolerance to many stresses and abolished or impaired the sexual life cycle. The chronological life span remained largely unaffected by domestication and was instead dictated by clade-specific evolution. We traced the genetic origins of the yeast domestication syndrome using genome-wide association analysis and genetic engineering and disclosed causative effects of aneuploidy, gene presence/absence variations, copy number variations and single-nucleotide polymorphisms. Overall, we propose domestication to be the most dramatic event in budding yeast evolution, raising questions about how much domestication has distorted our understanding of the natural biology of this key model species.


Matteo De Chiara

Université Côte d'Azur

Benjamin P. Barré

Université Côte d'Azur

Karl Persson

Chalmers, Biologi och bioteknik, Industriell bioteknik

Agurtzane Irizar

Université Côte d'Azur

Chiara Vischioni

Université Côte d'Azur

Sakshi Khaiwal

Université Côte d'Azur

Simon Stenberg

Göteborgs universitet

Amadi Onyetuga Chioma

Göteborgs universitet

Gašper Žun

Institut Jožef Stefan

Univerza V Ljubljani

Katja Doberšek

Institut Jožef Stefan

Cristian Taccioli

Università di Padova

Joseph Schacherer

Université de Strasbourg

Uros Petrovic

Institut Jožef Stefan

Univerza V Ljubljani

Jonas Warringer

Göteborgs universitet

Gianni Liti

Université Côte d'Azur

Nature Ecology & Evolution

2397-334X (ISSN) 2397-334X (eISSN)

Vol. 6





Bioinformatik och systembiologi




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