A Molybdenum Disulfide Nanozyme with Charge-Enhanced Activity for Ultrasound-Mediated Cascade-Catalytic Tumor Ferroptosis
Artikel i vetenskaplig tidskrift, 2023

The deficient catalytic activity of nanozymes and insufficient endogenous H2O2 in the tumor microenvironment (TME) are major obstacles for nanozyme-mediated catalytic tumor therapy. Since electron transfer is the basic essence of catalysis-mediated redox reactions, we explored the contributing factors of enzymatic activity based on positive and negative charges, which are experimentally and theoretically demonstrated to enhance the peroxidase (POD)-like activity of a MoS2 nanozyme. Hence, an acidic tumor microenvironment-responsive and ultrasound-mediated cascade nanocatalyst (BTO/MoS2@CA) is presented that is made from few-layer MoS2 nanosheets grown on the surface of piezoelectric tetragonal barium titanate (T-BTO) and modified with pH-responsive cinnamaldehyde (CA). The integration of pH-responsive CA-mediated H2O2 self-supply, ultrasound-mediated charge-enhanced enzymatic activity, and glutathione (GSH) depletion enables out-of-balance redox homeostasis, leading to effective tumor ferroptosis with minimal side effects.

Tumor Therapy

Nanozymes

Ferroptosis

Reactive Oxygen Species

Författare

Longwei Wang

Chinese Academy of Sciences

Northwest University

Xiaodi Zhang

Jinan University

Zhen You

Northwest University

Chinese Academy of Sciences

Zhongwei Yang

Jinan University

Mengyu Guo

Chinese Academy of Sciences

Jia Wei Guo

Jinan University

He Liu

Chinese Academy of Sciences

Xiaoyu Zhang

Chinese Academy of Sciences

Northwest University

Zhuo Wang

Chinese Academy of Sciences

Aizhu Wang

Jinan University

Yawei Lv

Hunan University

Jian Zhang

Chalmers, Arkitektur och samhällsbyggnadsteknik, Geologi och geoteknik

Xin Yu

Jinan University

Jing Liu

Northwest University

Chinese Academy of Sciences

Chunying Chen

Chinese Academy of Sciences

Angewandte Chemie - International Edition

1433-7851 (ISSN) 1521-3773 (eISSN)

Vol. 62 11 e202217448

Ämneskategorier

Medicinska grundvetenskaper

Fysik

Biologiska vetenskaper

Kemi

DOI

10.1002/anie.202217448

PubMed

36585377

Mer information

Senast uppdaterat

2023-03-16