Proteogenomics decodes the evolution of human ipsilateral breast cancer
Artikel i vetenskaplig tidskrift, 2023

Ipsilateral breast tumor recurrence (IBTR) is a clinically important event, where an isolated in-breast recurrence is a potentially curable event but associated with an increased risk of distant metastasis and breast cancer death. It remains unclear if IBTRs are associated with molecular changes that can be explored as a resource for precision medicine strategies. Here, we employed proteogenomics to analyze a cohort of 27 primary breast cancers and their matched IBTRs to define proteogenomic determinants of molecular tumor evolution. Our analyses revealed a relationship between hormonal receptors status and proliferation levels resulting in the gain of somatic mutations and copy number. This in turn re-programmed the transcriptome and proteome towards a highly replicating and genomically unstable IBTRs, possibly enhanced by APOBEC3B. In order to investigate the origins of IBTRs, a second analysis that included primaries with no recurrence pinpointed proliferation and immune infiltration as predictive of IBTR. In conclusion, our study shows that breast tumors evolve into different IBTRs depending on hormonal status and proliferation and that immune cell infiltration and Ki-67 are significantly elevated in primary tumors that develop IBTR. These results can serve as a starting point to explore markers to predict IBTR formation and stratify patients for adjuvant therapy.


Tommaso De Marchi

Lunds universitet

Paul Theodor Pyl

Science for Life Laboratory (SciLifeLab)

Martin Sjöström

University of California

Lunds universitet

Susanne Reinsbach

Chalmers, Life sciences, Systembiologi

Sebastian DiLorenzo

Uppsala universitet

Björn Nystedt

Uppsala universitet

Lena Tran

Lunds universitet

Gyula Pekar

Lunds universitet

Fredrik Wärnberg

Göteborgs universitet

Irma Fredriksson

Karolinska Institutet

Karolinska universitetssjukhuset

Per Malmström

Lunds universitet

Skånes universitetssjukhus (SUS)

Mårten Fernö

Lunds universitet

Lars Malmström

Lunds universitet

Johan Malmstöm

Lunds universitet

Emma Niméus

Skånes universitetssjukhus (SUS)

Lunds universitet

Communications Biology

23993642 (eISSN)

Vol. 6 1 139


Medicinsk genetik

Urologi och njurmedicin

Cancer och onkologi





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