Eco-friendly fabrication of nonenzymatic electrochemical sensor based on cobalt/polymelamine/nitrogen-doped graphitic-porous carbon nanohybrid material for glucose monitoring in human blood
Artikel i vetenskaplig tidskrift, 2023

The design and development of eco-friendly fabrication of cost-effective electrochemical nonenzymatic biosensors with enhanced sensitivity and selectivity are one of the emerging area in nanomaterial and analytical chemistry. In this aspect, we developed a facile fabrication of tertiary nanocomposite material based on cobalt and polymelamine/nitrogen-doped graphitic porous carbon nanohybrid composite (Co-PM-NDGPC/SPE) for the application as a nonenzymatic electrochemical sensor to quantify glucose in human blood samples. Co-PM-NDGPC/SPE nanocomposite electrode fabrication was achieved using a single-step electrodeposition method under cyclic voltammetry (CV) technique under 1 M NH4Cl solution at 20 constitutive CV cycles (sweep rate 20 mV/s). Notably, the fabricated nonenzymatic electroactive nanocomposite material exhibited excellent electrocatalytic sensing towards the quantification of glucose in 0.1 M NaOH over a wide concentration range from 0.03 to 1.071 mM with a sensitive limit of detection 7.8 μM. Moreover, the Co-PM-NDGPC nanocomposite electrode with low charge transfer resistance (Rct∼81 Ω) and high ionic diffusion indicates excellent stability, reproducibility, and high sensitivity. The fabricated nanocomposite materials exhibit a commendable sensing response toward glucose molecules present in the blood serum samples recommends its usage in real-time applications.

Nitrogen-doped graphitic porous carbon

Electrochemical sensor


Tertiary nanocomposite material

Glucose and human blood

SPE modified Electrode


Mari Elancheziyan

Saveetha School of Engineering

Kaohsiung Medical University

Karthikeyan Prakasham

Kaohsiung Medical University

Muthusankar Eswaran

Chalmers, Life sciences, Systembiologi

Kaohsiung Medical University

Murugesan Duraisamy

SSN College of Engineering

Kaohsiung Medical University

Sivarasan Ganesan

Kaohsiung Medical University

Siew Ling Lee

Universiti Teknologi Malaysia

Vinoth Kumar Ponnusamy

Kaohsiung Medical University

National Sun Yat-Sen University

Environmental Research

0013-9351 (ISSN) 1096-0953 (eISSN)

Vol. 223 115403


Analytisk kemi

Textil-, gummi- och polymermaterial






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