Silver Nanoparticles: Bactericidal and Mechanistic Approach against Drug Resistant Pathogens
Reviewartikel, 2023

This review highlights the different modes of synthesizing silver nanoparticles (AgNPs) from their elemental state to particle format and their mechanism of action against multidrug-resistant and biofilm-forming bacterial pathogens. Various studies have demonstrated that the AgNPs cause oxidative stress, protein dysfunction, membrane disruption, and DNA damage in bacteria, ultimately leading to bacterial death. AgNPs have also been found to alter the adhesion of bacterial cells to prevent biofilm formation. The benefits of using AgNPs in medicine are, to some extent, counter-weighted by their toxic effect on humans and the environment. In this review, we have compiled recent studies demonstrating the antibacterial activity of AgNPs, and we are discussing the known mechanisms of action of AgNPs against bacterial pathogens. Ongoing clinical trials involving AgNPs are briefly presented. A particular focus is placed on the mechanism of interaction of AgNPs with bacterial biofilms, which are a significant pathogenicity determinant. A brief overview of the use of AgNPs in other medical applications (e.g., diagnostics, promotion of wound healing) and the non-medical sectors is presented. Finally, current drawbacks and limitations of AgNPs use in medicine are discussed, and perspectives for the improved future use of functionalized AgNPs in medical applications are presented.

multidrug-resistant bacteria

biofilm forming organism

silver nanoparticles


Pragati Rajendra More

University of Campania Luigi Vanvitelli

Santosh Pandit

Chalmers, Life sciences, Systembiologi

Anna De Filippis

University of Campania Luigi Vanvitelli

Gianluigi Franci

Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana"

Ivan Mijakovic

Danmarks Tekniske Universitet (DTU)

Chalmers, Life sciences, Systembiologi

Massimiliano Galdiero

University of Campania Luigi Vanvitelli


20762607 (eISSN)

Vol. 11 2 369

Förstå interaktionen mellan grafenbaserad beläggning på tandimplantat och perio-implantibakterier

Vetenskapsrådet (VR) (2020-04096), 2021-01-01 -- 2024-12-31.



Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Mikrobiologi inom det medicinska området





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