Antibiotic-Loaded Boron Nitride Nanoconjugate with Strong Performance against Planktonic Bacteria and Biofilms
Artikel i vetenskaplig tidskrift, 2023

Protecting surfacesfrom biofilm formation presents a significantchallenge in the biomedical field. The utilization of antimicrobialcomponent-conjugated nanoparticles is becoming an attractive strategyagainst infectious biofilms. Boron nitride (BN) nanomaterials havea unique biomedical application value due to their excellent biocompatibility.Here, we developed antibiotic-loaded BN nanoconjugates to combat bacterialbiofilms. Antibiofilm testing included two types of pathogens, Staphylococcus aureus and Escherichiacoli. Gentamicin was loaded on polydopamine-modifiedBN nanoparticles (GPBN) to construct a nanoconjugate, which was veryeffective in killing E. coli and S. aureus planktonic cells. GPBN exhibited equallystrong capacity for biofilm destruction, tested on preformed biofilms.A 24 h treatment with the nanoconjugate reduced cell viability bymore than 90%. Our results suggest that GPBN adheres to the surfaceof the biofilm, penetrates inside the biofilm matrix, and finallydeactivates the cells. Interestingly, the GPBN coatings also stronglyinhibited the formation of bacterial biofilms. Based on these results,we suggest that GPBN could serve as an effective means for treatingbiofilm-associated infections and as coatings for biofilm prevention.

gentamicin

polydopamine

boron nitride

antibacterial

antibiofilm

Författare

Jian Zhang

Chalmers, Life sciences, Systembiologi

Nisha Neupane

Student vid Chalmers

Tribhuvan University

Puspa Raj Dahal

Tribhuvan University

Shadi Rahimi

Chalmers, Life sciences, Systembiologi

Zhejian Cao

Chalmers, Life sciences, Systembiologi

Santosh Pandit

Chalmers, Life sciences, Systembiologi

Ivan Mijakovic

Chalmers, Life sciences, Systembiologi

ACS Applied Bio Materials

25766422 (eISSN)

Vol. 6 8 3131-3142

Ämneskategorier

Mikrobiologi inom det medicinska området

Medicinska material och protesteknik

DOI

10.1021/acsabm.3c00247

PubMed

37473743

Mer information

Senast uppdaterat

2024-03-07