Biomimetic nanoscale reactors and networks
Artikel i vetenskaplig tidskrift, 2004

Methods based on self-assembly, self-organization, and forced shape transformations to form synthetic or semisynthetic enclosed lipid bilayer structures with several properties similar to biological nanocompartments are reviewed. The procedures offer unconventional micro- and nanofabrication routes to yield complex soft-matter devices for a variety of applications for example, in physical chemistry and nanotechnology. In particular, we describe novel micromanipulation methods for producing fluid-state lipid bilayer networks of nanotubes and surface-immobilized vesicles with controlled geometry, topology, membrane composition, and interior contents. Mass transport in nanotubes and materials exchange, for example, between conjugated containers, can be controlled by creating a surface tension gradient that gives rise to a moving boundary or by induced shape transformations. The network devices can operate with extremely small volume elements and low mass, to the limit of single molecules and particles at a length scale where a continuum mechanics approximation may break down. Thus, we also describe some concepts of anomalous fluctuation-dominated kinetics and anomalous diffusive behaviours, including hindered transport, as they might become important in studying chemistry and transport phenomena in these confined systems. The networks are suitable for initiating and controlling chemical reactions in confined biomimetic compartments for rationalizing, for example, enzyme behaviors, as well as for applications in nanofluidics, bioanalytical devices, and to construct computational and complex sensor systems with operations building on chemical kinetics, coupled reactions and controlled mass transport.

chemistry

Liposomes

chemistry

Surface-Active Agents

Microfluidics

methods

Fluorescence

Biomimetic Materials

chemistry

Lipid Bilayers

Nanotechnology

Membrane Lipids

Microscopy

Biological Transport

chemistry

methods

chemistry

Författare

Mattias Karlsson

Chalmers University of Technology

Microtechnology Cent

M. Davidson

Microtechnology Cent

Chalmers University of Technology

Roger Karlsson

Göteborgs universitet

A. Karlsson

Göteborgs universitet

Chalmers University of Technology

Johan Bergenholtz

Göteborgs universitet

Zoran Konkoli

Chalmers, Teknisk fysik, Kondenserade materiens teori

Aldo Jesorka

Chalmers, Institutionen för kemi och biovetenskap

Tatsiana Lobovkina

Chalmers, Institutionen för kemi och biovetenskap

Johan Hurtig

Microtechnology Cent

Chalmers University of Technology

Marina Voinova

Chalmers, Teknisk fysik, Kondenserade materiens teori

Owe Orwar

Chalmers, Institutionen för kemi och biovetenskap, Fysikalisk kemi

Annual Review of Physical Chemistry

0066-426X (ISSN) 1545-1593 (eISSN)

Vol. 55 613-49

Ämneskategorier

Fysikalisk kemi

DOI

10.1146/annurev.physchem.55.091602.094319

PubMed

15117264