A comprehensive review on Moringa oleifera nanoparticles: importance of polyphenols in nanoparticle synthesis, nanoparticle efficacy and their applications
Reviewartikel, 2024

Moringa oleifera is one of the popular functional foods that has been tremendously exploited for synthesis of a vast majority of metal nanoparticles (NPs). The diverse secondary metabolites present in this plant turn it into a green tool for synthesis of different NPs with various biological activities. In this review, we discussed different types of NPs including silver, gold, titanium oxide, iron oxide, and zinc oxide NPs produced from the extract of different parts of M. oleifera. Different parts of M. oleifera take a role as the reducing, stabilizing, capping agent, and depending on the source of extract, the color of solution changes within NP synthesis. We highlighted the role of polyphenols in the synthesis of NPs among major constituents of M. oleifera extract. The different synthesis methods that could lead to the formation of various sizes and shapes of NPs and play crucial role in biomedical application were critically discussed. We further debated the mechanism of interaction of NPs with various sizes and shapes with the cells, and further their clearance from the body. The application of NPs made from M. oleifera extract as anticancer, antimicrobial, wound healing, and water treatment agent were also discussed. Small NPs show better antimicrobial activity, while they can be easily cleared from the body through the kidney. In contrast, large NPs are taken by the mono nuclear phagocyte system (MPS) cells. In case of shape, the NPs with spherical shape penetrate into the bacteria, and show stronger antibacterial activity compared to the NPs with other shapes. Finally, this review aims to correlate the key characteristics of NPs made from M. oleifera extract, such as size and shape, to their interactions with the cells for designing and engineering them for bio-applications and especially for therapeutic purposes. Graphical Abstract: (Figure presented.)

Metal nanoparticles

Critical parameters

Secondary metabolites

Green synthesis

Moringa nanoparticles

Application of Moringa nanoparticles

Författare

Haribalan Perumalsamy

Hanyang University

Sri Renukadevi Balusamy

Sejong University

Johan Sukweenadhi

Universitas Surabaya

Sagnik Nag

Monash University Malaysia

Davoodbasha MubarakAli

B.S.Abdur Rahman University

Mohamed El-Agamy Farh

Yonsei University

Hari Vijay

Saveetha Medical College and Hospital

Shadi Rahimi

Chalmers, Life sciences, Systembiologi

Journal of Nanobiotechnology

14773155 (eISSN)

Vol. 22 1 71

Ämneskategorier

Industriell bioteknik

Livsmedelsvetenskap

Bioinformatik och systembiologi

DOI

10.1186/s12951-024-02332-8

PubMed

38373982

Mer information

Senast uppdaterat

2024-03-05