Glycemic variability assessed using continuous glucose monitoring in individuals without diabetes and associations with cardiometabolic risk markers: A systematic review and meta-analysis
Artikel i vetenskaplig tidskrift, 2024

Background & aims:
Continuous glucose monitoring (CGM) provides data on short-term glycemic variability (GV). GV is associated with adverse outcomes in individuals with diabetes. Whether GV is associated with cardiometabolic risk in individuals without diabetes is unclear. We systematically reviewed the literature to assess whether GV is associated with cardiometabolic risk markers or outcomes in individuals without diabetes.
Methods:
Searches were performed in PubMed/Medline, Embase and Cochrane from inception through April 2022. Two researchers were involved in study selection, data extraction and quality assessment. Studies evaluating GV using CGM for ≥24 h were included. Studies in populations with acute and/or critical illness were excluded. Both narrative synthesis and meta-analyzes were performed, depending on outcome.
Results:
Seventy-one studies were included; the majority were cross-sectional. Multiple measures of GV are higher in individuals with compared to without prediabetes and GV appears to be inversely associated with beta cell function. In contrast, GV is not clearly associated with insulin sensitivity, fatty liver disease, adiposity, blood lipids, blood pressure or oxidative stress. However, GV may be positively associated with the degree of atherosclerosis and cardiovascular events in individuals with coronary disease.
Conclusion:
GV is elevated in prediabetes, potentially related to beta cell dysfunction, but less clearly associated with obesity or traditional risk factors. GV is associated with coronary atherosclerosis development and may predict cardiovascular events and type 2 diabetes. Prospective studies are warranted, investigating the predictive power of GV in relation to incident disease. GV may be an important risk measure also in individuals without diabetes.

Prediabetes

Continuous glucose monitoring

Glycemic variability

Atherosclerosis

Cardiovascular disease

Type 2 diabetes

Författare

Anna Hjort

Chalmers, Life sciences, Livsmedelsvetenskap

David Iggman

Uppsala universitet

Fredrik Rosqvist

Uppsala universitet

Clinical Nutrition

0261-5614 (ISSN) 15321983 (eISSN)

Vol. 43 4 915-925

Ämneskategorier

Endokrinologi och diabetes

Kardiologi

Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

Näringslära

DOI

10.1016/j.clnu.2024.02.014

PubMed

38401227

Mer information

Senast uppdaterat

2024-03-12