Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition
Artikel i vetenskaplig tidskrift, 2025
Background/Objectives: We examined the association between dietary intake and blood concentrations of one-carbon metabolism (OCM)-related nutrients in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Blood concentrations and dietary intake of the vitamins riboflavin (B2), Pyridoxal 5′-phosphate (PLP and B6), folate (B9), B12, and methionine, concentrations of homocysteine, and dietary intake of betaine, choline, and cysteine were pooled from 16,267 participants in nine EPIC nested case–control studies. Correlation analyses between dietary intakes and blood concentrations were carried out. Principal component (PC) analysis identified latent factors in the two sets of measurements.
Results: Pearson correlations between dietary intakes and blood concentrations ranged from 0.08 for methionine to 0.12 for vitamin B2, 0.15 for vitamin B12, 0.17 for vitamin B6, and 0.19 for folate. Individual dietary intakes showed higher correlations (ranging from −0.14 to 0.82) compared to individual blood concentrations (from −0.31 to 0.29). Correlations did not vary by smoking status, case–control status, or vitamin supplement use. The first PC of dietary intakes was mostly associated with methionine, vitamin B12, cysteine, and choline, while the first PC of blood concentrations was associated with folate and vitamin B6.
Conclusions: Within this large European study, we found weak to moderate associations between dietary intakes and concentrations of OCM-related nutrients.
Results: Pearson correlations between dietary intakes and blood concentrations ranged from 0.08 for methionine to 0.12 for vitamin B2, 0.15 for vitamin B12, 0.17 for vitamin B6, and 0.19 for folate. Individual dietary intakes showed higher correlations (ranging from −0.14 to 0.82) compared to individual blood concentrations (from −0.31 to 0.29). Correlations did not vary by smoking status, case–control status, or vitamin supplement use. The first PC of dietary intakes was mostly associated with methionine, vitamin B12, cysteine, and choline, while the first PC of blood concentrations was associated with folate and vitamin B6.
Conclusions: Within this large European study, we found weak to moderate associations between dietary intakes and concentrations of OCM-related nutrients.
dietary B-vitamins
nutrients
one-carbon metabolism
blood B-vitamin concentrations
partial least square path modeling
EPIC
principal component analysis
Författare
Jin Young Park
International Agency for Research on Cancer (IARC)
Heleen Van Puyvelde
International Agency for Research on Cancer (IARC)
Universiteit Gent
Lea Regazzetti
International Agency for Research on Cancer (IARC)
Joanna L. Clasen
Imperial College London
University of South Florida
Alicia K. Heath
Imperial College London
Simone Eussen
Universiteit Maastricht
Per M. Ueland
Bevital AS
Mattias Johansson
International Agency for Research on Cancer (IARC)
Carine Biessy
International Agency for Research on Cancer (IARC)
Raul Zamora-Ros
Institut d'Investigació Biomedica de Bellvitge
José María Huerta
Health Council of Murcia
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Maria Jose Sánchez
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Escuela Andaluza Salud Publica
Instituto de Investigación Biosanitaria ibs.GRANADA
Universidad de Granada
Marga Ocke
Netherlands National Institute Public Health and the Environment
Matthias B. Schulze
Deutsches Institut für Ernährungsforschung
Universität Potsdam
Catarina Schiborn
Deutsches Institut für Ernährungsforschung
Tonje Bjørndal Braaten
Universitetet i Tromsø – Norges arktiske universitet
Guri Skeie
Universitetet i Tromsø – Norges arktiske universitet
Carlotta Sacerdote
Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino
Jesús Castilla
Instituto de Investigación Sanitaria de Navarra (IdiSNA)
Instituto de Salud Publica, Pamplona
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Therese Karlsson
Chalmers, Life sciences, Livsmedelsvetenskap
Göteborgs universitet
Ingegerd Johansson
Umeå universitet
C. Kyro
Danish Cancer Research Society Center
Anne Tjønneland
Danish Cancer Research Society Center
Tammy Y.N. Tong
University of Oxford
Verena Katzke
Deutsches Krebsforschungszentrum (DKFZ)
Rashmita Bajracharya
Deutsches Krebsforschungszentrum (DKFZ)
Cristina Lasheras
Universidad de Oviedo
Øivind Midttun
Bevital AS
Stein Emil Vollset
School of Medicine
Paolo Vineis
Imperial College London
Giovanna Masala
Istituto per lo Studio, la Prevenzione e la Rete Oncologica
Pilar Amiano
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Ministry of Health of the Basque Government
Biodonostia Health Research Institute
Rosario Tumino
Hyblean Association for Epidemiological Research
Ivan Baldassari
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Elisabete Weiderpass
International Agency for Research on Cancer (IARC)
Elio Riboli
Universiteit Gent
Marc J. Gunter
International Agency for Research on Cancer (IARC)
Imperial College London
Heinz Freisling
International Agency for Research on Cancer (IARC)
Sabina Rinaldi
International Agency for Research on Cancer (IARC)
David C. Muller
Imperial College London
Inge Huybrechts
International Agency for Research on Cancer (IARC)
Pietro Ferrari
International Agency for Research on Cancer (IARC)
Nutrients
2072-6643 (ISSN) 20726643 (eISSN)
Vol. 17 12 1970Ämneskategorier (SSIF 2025)
Cancer och onkologi
Näringslära och dietkunskap
Arbetsmedicin och miljömedicin
DOI
10.3390/nu17121970