Stable BF2 Boracycles as Versatile Reagents for Selective Ortho C–H Functionalization
Artikel i vetenskaplig tidskrift, 2026
The development of new boron reagents continues to play a crucial role in advancing modern organic synthesis, particularly in C–H functionalization and cross-coupling reactions. Herein, we report a metal-free, robust, and scalable multigram protocol for the synthesis of stable BF2 boracycles that require no column chromatography, providing a practical and efficient route to access this valuable boron species. The BF2 boracycles exhibit enhanced stability and reactivity, making them highly versatile intermediates for late-stage diversification. They undergo ipso-substitution to afford a wide array of derivatives, including halogenated (e.g., radioiodinated), hydroxylated, and azidated products. Furthermore, they display excellent reactivity in Suzuki–Miyaura cross-coupling reactions, enabling both C(sp2)─C(sp2) and C(sp2)─C(sp3) bond formation. These results underscore the utility of BF2 boracycles as powerful tools for selective functionalization in pharmaceutical synthesis and beyond. Our work represents a significant advancement in organoboron chemistry, offering both a streamlined synthetic approach and broad applicability for complex molecule construction.
BBr3
Cross-coupling
Radioiodination
Boron
Late-stage functionalization
Författare
Ganesh H. Shinde
Göteborgs universitet
Jonatan Babiker
Göteborgs universitet
Michelle Mebrahtu
Göteborgs universitet
Anaïs Prigent
CERMN - Centre d'Etudes et de Recherche sur le Médicament de Normandie
Centre François Baclesse
Gauthier Foucras
Centre François Baclesse
CERMN - Centre d'Etudes et de Recherche sur le Médicament de Normandie
Yogesh N. Aher
Göteborgs universitet
Francoise Mystere Amombo Noa
Chalmers, Kemi och kemiteknik, Kemi och biokemi
Magnus J. Johansson
AstraZeneca AB
Janez Košmrlj
Univerza V Ljubljani
Ross D. Jansen-van Vuuren
Univerza V Ljubljani
Thomas Cailly
Normandie Université
Hopital Cote de Nacre
Institut Blood and Brain @ Caen Normandie (BB@C)
CERMN - Centre d'Etudes et de Recherche sur le Médicament de Normandie
Henrik Sundén
Göteborgs universitet
AstraZeneca AB
Angewandte Chemie
14337851 (ISSN) 15213773 (eISSN)
Vol. 65 8 e18421Ämneskategorier (SSIF 2025)
Organisk kemi
DOI
10.1002/anie.202518421