Incidence of CSF abnormalities in siblings of multiple sclerosis patients and unrelated controls.
Artikel i vetenskaplig tidskrift, 2000

We found that 19% (9/47) of healthy siblings of patients with clinically definite multiple sclerosis had an intrathecal immunological reaction with two or more 2 CSF-enriched oligoclonal bands (OCBs), in contrast to (4%) (2/50) unrelated healthy controls. Furthermore, in this group of nine healthy sibs the measles CSF IgG antibody titers were higher than that of the other sibs and that of controls. There were also differences in the serum titers for measles IgG antibody, which were higher in the group of all healthy sibs than in healthy volunteers, and (as with CSF titers) higher in the subgroup of healthy sibs with two or more 2 CSF-enriched OCBs than the other sibs. Thus a significant proportion of healthy siblings to MS patients have a partially hyperimmune condition similar to that occurring in MS, which in 19% manifested itself as an OCB reaction, in 9% as increased CSF measles IgG antibody titers, and in 21% as increased serum measles IgG antibody titers, these phenomena tending to occur in the same individuals. This condition is characterized by CSF-enriched OCBs with undefined specificity, although some increased antiviral reactivity is found both in the serum and CSF. While it needs further characterization, a genetic trait interacting with common infections is suggested. The recurrence risk of this condition is approximately five times higher than the 3-4% recurrence risk for manifest MS reported for sibs.

immunology

immunology

Antibody Formation

Enzyme-Linked Immunosorbent Assay

Multiple Sclerosis

Family Health

Adult

Female

Humans

Case-Control Studies

immunology

immunology

Male

Adolescent

Phenotype

Measles

Autoimmune Diseases

genetics

cerebrospinal fluid

Middle Aged

Immunoglobulin G

Aged

Författare

Sara Haghighi

Göteborgs universitet

Oluf Andersen

Göteborgs universitet

Lars Rosengren

Göteborgs universitet

Tomas Bergström

Göteborgs universitet

Jan Wahlström

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Institutionen för matematik, Matematisk statistik

Journal of Neurology

0340-5354 (ISSN)

Vol. 247 616-22

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

PubMed

11041329