Association between a dinucleotide repeat polymorphism of the estrogen receptor alpha gene and personality traits in women.
Artikel i vetenskaplig tidskrift, 2003

Estrogens are known to play a key role in the regulation of various aspects of behavior. In order to study the potential contribution of genetic variation in the estrogen receptor (ER) alpha to specific personality traits, we investigated a repeat polymorphism in the ER alpha gene in 172 42-year-old women who had been assessed using the Karolinska Scales of Personality (KSP). Based on the hypothesis that there is a relationship between the length of a repeat polymorphism and gene function,(1) the alleles were divided into two groups: short and long. In order to elucidate the possible influence of the ER alpha gene on the different aspects of personality measured by means of the KSP, the possible association between this gene and four different factors ('neuroticism', 'psychoticism', 'non-conformity', and 'extraversion') was analysed. 'Neuroticism', 'psychoticism', and 'non-conformity' all appeared to be associated with the ER alpha gene. After correction for multiple comparisons by means of permutation analysis, the associations with the factor 'non-conformity'--including the subscales 'indirect aggression' and 'irritability'--and the factor 'psychoticism'--including the subscale 'suspicion'--remained significant. The results suggest that the studied dinucleotide repeat polymorphism of the ER alpha gene may contribute to specific components of personality.

Polymorphism

Estrogen Receptor alpha

Receptors

physiology

physiology

genetics

Irritable Mood

genetics

Adult

genetics

Estrogen

Anxiety

Female

Neurotic Disorders

Dinucleotide Repeats

Humans

Personality

Genetic

Aggression

genetics

Författare

Lars Westberg

Göteborgs universitet

Jonas Melke

Göteborgs universitet

Mikael Landén

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Chalmers, Institutionen för matematisk statistik

Fariba Baghaei

Göteborgs universitet

Roland Rosmond

Göteborgs universitet

M Jansson

Göteborgs universitet

Göran Holm

Göteborgs universitet

Per Björntorp

Göteborgs universitet

Elias Eriksson

Göteborgs universitet

Molecular Psychiatry

1359-4184 (ISSN) 1476-5578 (eISSN)

Vol. 8 1 118-22

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

DOI

10.1038/sj.mp.4001192

PubMed

12556917