A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women.
Artikel i vetenskaplig tidskrift, 2003

BACKGROUND: The brain neurotransmitter serotonin is known to affect various aspects of human behavior, including personality traits. Serotonin receptor type 3 is a ligand-gated channel encoded by 2 different subunit genes, HTR3A and HTR3B. A polymorphism (C178T) in the 5' region of the HTR3A gene has recently been identified and suggested to be of functional importance. OBJECTIVE: To elucidate the possible association between the C178T polymorphism in the HTR3A gene and personality traits in women. DESIGN: Two independent samples of 35- to 45-year-old Swedish women were recruited using the population register. Sample 1 (n = 195) was assessed via the Karolinska Scales of Personality and the Temperament and Character Inventory; sample 2 (n = 175) was assessed using the latter only. Both samples were genotyped with respect to the C178T polymorphism in the HTR3A gene. The A1596G polymorphism in the same gene was also investigated. RESULTS: A significant association between C178T genotype and the Temperament and Character Inventory factor harm avoidance was observed in sample 1 (corrected for multiple comparisons P =.04); this finding was subsequently replicated in sample 2 (P =.004) (pooled populations: P<.001). In the pooled sample, all harm avoidance subscales were found to be significantly associated with the C178T polymorphism: anticipatory worry (P =.001), fear of uncertainty (P<.001), shyness (P<.001), and fatigability and asthenia (P =.008). In addition, a significant association was found in sample 1 between the C178T polymorphism and the Karolinska Scales of Personality nonconformity factor (corrected P =.002), including the subscales of social desirability (P<.001), indirect aggression (P =.002), verbal aggression (P =.05), and irritability (P<.001). Participants homozygous for the less common T allele (<4%) differed from the remaining women by displaying lower ratings on harm avoidance and nonconformity. CONCLUSION: The C178T polymorphism in the HTR3A gene may affect the personality trait of harm avoidance in women.

Serine Endopeptidases

genetics

Personality Assessment

Personality Inventory

Humans

Serotonin

Sweden

Receptors

genetics

Personality

Female

Genotype

Adult

5-HT3

genetics

Middle Aged

Genetic

genetics

Cohort Studies

Polymorphism

classification

Författare

Jonas Melke

Göteborgs universitet

Lars Westberg

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Chalmers, Institutionen för matematisk statistik

Mikael Landén

Göteborgs universitet

Henrik Söderström

Göteborgs universitet

Fariba Baghaei

Göteborgs universitet

Roland Rosmond

Göteborgs universitet

Göran Holm

Göteborgs universitet

Per Björntorp

Göteborgs universitet

Lars-Göran Nilsson

Stockholms universitet

Rolf Adolfsson

Umeå universitet

Elias Eriksson

Göteborgs universitet

Archives of General Psychiatry

0003-990X (ISSN)

Vol. 60 1017-23

Ämneskategorier

Psykiatri

MEDICIN OCH HÄLSOVETENSKAP

DOI

10.1001/archpsyc.60.10.1017

PubMed

14557147