Polymorphisms in oestrogen and progesterone receptor genes: possible influence on prolactin levels in women.
Artikel i vetenskaplig tidskrift, 2004
OBJECTIVE: Oestrogen and progesterone are known to influence the release of human prolactin. The present study was undertaken in order to investigate the possible influence of polymorphisms of the genes encoding the oestrogen receptor (ER)alpha, ERbeta and the progesterone receptor (PGR), on prolactin levels in premenopausal women. DESIGN AND MEASUREMENTS: Serum levels of prolactin were measured in the follicular phase of the menstrual cycle. Subjects were genotyped with respect to a TA repeat polymorphism of the ERalpha gene, a CA repeat polymorphism of the ERbeta gene, and two polymorphisms of the PGR gene: one insertion polymorphism (PROGINS) and one single nucleotide polymorphism (G331A). SUBJECTS: A population-based cohort of 270 42-year-old women. RESULTS: The CA repeat polymorphism of the ERbeta gene and the G331A polymorphism of the PGR gene appeared to be associated with prolactin levels. In contrast, we found no evidence for an influence of the PROGINS polymorphism of the PGR gene or the TA repeat polymorphism of the ERalpha gene on the levels of this hormone. CONCLUSIONS: These data suggest that genetic variants of both the ERbeta and the PGR may influence prolactin release.
Genotype
Polymorphism
blood
Progesterone
Follicular Phase
Receptors
Estrogen Receptor alpha
Genetic
Cohort Studies
Female
Single Nucleotide
Repetitive Sequences
genetics
genetics
Estrogen
genetics
DNA Transposable Elements
Estrogen Receptor beta
Polymorphism
genetics
genetics
blood
Smoking
Receptors
Nucleic Acid
genetics
Prolactin
Humans
genetics
Adult
Författare
Lars Westberg
Göteborgs universitet
Hoi-Por Ho
Göteborgs universitet
Fariba Baghaei
Göteborgs universitet
Staffan Nilsson
Göteborgs universitet
Chalmers, Institutionen för matematisk statistik
Jonas Melke
Göteborgs universitet
Roland Rosmond
Göteborgs universitet
Göran Holm
Göteborgs universitet
Per Björntorp
Göteborgs universitet
Elias Eriksson
Göteborgs universitet
Clinical Endocrinology
0300-0664 (ISSN) 1365-2265 (eISSN)
Vol. 61 2 216-23Ämneskategorier
MEDICIN OCH HÄLSOVETENSKAP
DOI
10.1111/j.1365-2265.2004.02083.x
PubMed
15272917