Polymorphisms in oestrogen and progesterone receptor genes: possible influence on prolactin levels in women.
Artikel i vetenskaplig tidskrift, 2004

OBJECTIVE: Oestrogen and progesterone are known to influence the release of human prolactin. The present study was undertaken in order to investigate the possible influence of polymorphisms of the genes encoding the oestrogen receptor (ER)alpha, ERbeta and the progesterone receptor (PGR), on prolactin levels in premenopausal women. DESIGN AND MEASUREMENTS: Serum levels of prolactin were measured in the follicular phase of the menstrual cycle. Subjects were genotyped with respect to a TA repeat polymorphism of the ERalpha gene, a CA repeat polymorphism of the ERbeta gene, and two polymorphisms of the PGR gene: one insertion polymorphism (PROGINS) and one single nucleotide polymorphism (G331A). SUBJECTS: A population-based cohort of 270 42-year-old women. RESULTS: The CA repeat polymorphism of the ERbeta gene and the G331A polymorphism of the PGR gene appeared to be associated with prolactin levels. In contrast, we found no evidence for an influence of the PROGINS polymorphism of the PGR gene or the TA repeat polymorphism of the ERalpha gene on the levels of this hormone. CONCLUSIONS: These data suggest that genetic variants of both the ERbeta and the PGR may influence prolactin release.

Genotype

Polymorphism

blood

Progesterone

Follicular Phase

Receptors

Estrogen Receptor alpha

Genetic

Cohort Studies

Female

Single Nucleotide

Repetitive Sequences

genetics

genetics

Estrogen

genetics

DNA Transposable Elements

Estrogen Receptor beta

Polymorphism

genetics

genetics

blood

Smoking

Receptors

Nucleic Acid

genetics

Prolactin

Humans

genetics

Adult

Författare

Lars Westberg

Göteborgs universitet

Hoi-Por Ho

Göteborgs universitet

Fariba Baghaei

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Chalmers, Institutionen för matematisk statistik

Jonas Melke

Göteborgs universitet

Roland Rosmond

Göteborgs universitet

Göran Holm

Göteborgs universitet

Per Björntorp

Göteborgs universitet

Elias Eriksson

Göteborgs universitet

Clinical Endocrinology

0300-0664 (ISSN) 1365-2265 (eISSN)

Vol. 61 2 216-23

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

DOI

10.1111/j.1365-2265.2004.02083.x

PubMed

15272917