Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women.
Artikel i vetenskaplig tidskrift, 2004

Although genetic factors are known to be important risk factors for panic disorder there is as yet no conclusive data regarding specific gene variants. Prompted by evidence supporting progesterone to influence the pathophysiology of panic disorder, polymorphisms in the progesterone receptor gene, a single nucleotide polymorphism (G331A) and an insertion/deletion polymorphism (PROGINS) were investigated in 72 patients with panic disorder and 452 controls. The frequency of the A-allele of the G331A polymorphism was higher in panic disorder patients than in controls (p = 0.01). When male and female patients were analyzed separately, the association was observed in female patients only (p = 0.0009), with an odds ratio of 3.5. No differences between groups were observed for the PROGINS polymorphism. In conclusion, these data suggest that the G331A polymorphism in the progesterone receptor gene may influence the risk for panic disorder in women.

Humans

genetics

Female

Risk Factors

Receptors

Male

genetics

Human

Chromosomes

Sex Factors

Gene Frequency

genetics

Genetic Predisposition to Disease

Single Nucleotide

genetics

Polymorphism

Panic Disorder

Pair 11

Progesterone

Författare

Hoi-Por Ho

Göteborgs universitet

Lars Westberg

Göteborgs universitet

Kristina Annerbrink

Göteborgs universitet

Marie Olsson

Göteborgs universitet

Jonas Melke

Göteborgs universitet

Staffan Nilsson

Chalmers, Institutionen för matematisk statistik

Göteborgs universitet

Fariba Baghaei

Göteborgs universitet

Roland Rosmond

Göteborgs universitet

Göran Holm

Göteborgs universitet

Per Björntorp

Göteborgs universitet

Sven Andersch

Göteborgs universitet

Christer Allgulander

Karolinska Institutet

Elias Eriksson

Göteborgs universitet

Psychoneuroendocrinology

0306-4530 (ISSN)

Vol. 29 1138-41

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

DOI

10.1016/j.psyneuen.2004.01.005

PubMed

15219637