Investigation of genes coding for inflammatory components in Parkinson's disease.
Artikel i vetenskaplig tidskrift, 2005

Several findings obtained recently indicate that inflammation may contribute to the pathogenesis in Parkinson's disease (PD). Genetic variants of genes coding for components involved in immune reactions in the brain might therefore influence the risk of developing PD or the age of disease onset. Five single nucleotide polymorphisms (SNPs) in the genes coding for interferon-gamma (IFN-gamma; T874A in intron 1), interferon-gamma receptor 2 (IFN-gamma R2; Gln64Arg), interleukin-10 (IL-10; G1082A in the promoter region), platelet-activating factor acetylhydrolase (PAF-AH; Val379Ala), and intercellular adhesion molecule 1 (ICAM-1; Lys469Glu) were genotyped, using pyrosequencing, in 265 patients with PD and 308 controls. None of the investigated SNPs was found to be associated with PD; however, the G1082A polymorphism in the IL-10 gene promoter was found to be related to the age of disease onset. Linear regression showed a significantly earlier onset with more A-alleles (P = 0.0095; after Bonferroni correction, P = 0.048), resulting in a 5-year delayed age of onset of the disease for individuals having two G-alleles compared with individuals having two A-alleles. The results indicate that the IL-10 G1082A SNP could possibly be related to the age of onset of PD.

Promoter Regions (Genetics)

genetics

metabolism

Interleukin-10

DNA Primers

genetics

Parkinson Disease

Interferon

genetics

genetics

genetics

genetics

Interferon Type II

metabolism

Age Factors

Polymorphism

Chemokine CCL2

genetics

genetics

Intercellular Adhesion Molecule-1

metabolism

genetics

genetics

1-Alkyl-2-acetylglycerophosphocholine Esterase

Alleles

genetics

metabolism

Inflammation

metabolism

metabolism

complications

Genotype

Brain

Receptors

genetics

metabolism

Humans

Tumor Necrosis Factor-alpha

Genetic

complications

Middle Aged

metabolism

metabolism

metabolism

Författare

Anna Håkansson

Göteborgs universitet

Lars Westberg

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

Silvia Buervenich

Karolinska Institutet

A Carmine

Karolinska Institutet

Björn Holmberg

Göteborgs universitet

O Sydow

Karolinska Institutet

L Olson

Karolinska Institutet

Bo Johnels

Göteborgs universitet

Elias Eriksson

Göteborgs universitet

Hans Nissbrandt

Göteborgs universitet

Movement Disorders

0885-3185 (ISSN) 1531-8257 (eISSN)

Vol. 20 5 569-73

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

DOI

10.1002/mds.20378

PubMed

15648059