Clinical mass spectrometry in neuroscience. Proteomics and peptidomics.
Reviewartikel, 2003

In this review we discuss the merits and drawbacks with the use of proteomic and peptidomic strategies for identification of proteins and peptides in their multidimensional interactions in complex biological processes. The progress in proteomics and peptidomics during the last years offer us new challenges to study changes in the protein and peptide synthesis. These strategies also offer new tools to follow post-translational modifications and other disturbed chemical processes that may be indicative of pathophysiological alteration(s). Furthermore these techniques can contribute to improvements in the diagnosis and therapy of neurodegenerative diseases, such as Alzheimer's disease, and psychiatric diseases, as depression and post traumatic stress disorders. We also consider different practical aspects of the applications of mass spectrometry in clinical neuroscience, illustrated by example from our laboratories. The new proteomic and peptidomic strategies will further enable the progress for clinical neuroscience research.

metabolism

metabolism

metabolism

Arteriosclerosis

diagnosis

methods

metabolism

diagnosis

analysis

Proteomics

Proteins

chemistry

diagnosis

Mass Spectrometry

Dementia

Central Nervous System Diseases

methods

metabolism

Brain Neoplasms

Humans

Cerebrospinal Fluid

Peptides

diagnosis

analysis

Neurosciences

Författare

Pia Davidsson

Göteborgs universitet

Ann Brinkmalm-Westman

Göteborgs universitet

G Karlsson

Göteborgs universitet

R Persson

Göteborgs universitet

Maria Lindbjer

Göteborgs universitet

Maja Puchades

Göteborgs universitet

S Folkesson

Göteborgs universitet

Linda Paulson

Göteborgs universitet

Annika Dahl

Göteborgs universitet

Lars Rymo

Göteborgs universitet

J Silberring

Rolf Ekman

Göteborgs universitet

Kaj Blennow

Göteborgs universitet

Cellular and Molecular Biology

0145-5680 (ISSN) 1165-158X (eISSN)

Vol. 49 5 681-8

Ämneskategorier

Fysiologi

PubMed

14528905