Determination of the triplet state energies of a series of conjugated porphyrin oligomers
Artikel i vetenskaplig tidskrift, 2007

We report a systematic study of the photophysical parameters relevant to photodynamic therapy (PDT) by a new type of sensitizers, conjugated porphyrin oligomers. Due to the strong nonlinear properties of oligomers containing 2, 4 and 8 porphyrin units, these molecules are attractive candidates for PDT via multiphoton excitation. The triplet state energy levels for all molecules have been determined by the triplet quenching method, phosphorescence measurements and DFT calculations. We find that the triplet energies of all the oligomers are sufficient to generate singlet oxygen, > 94 kJ mol(-1). However, low singlet oxygen quantum yields are observed for the tetramer and the octamer, as compared to the conjugated dimer and monomeric porphyrin, reflecting the decrease in triplet yield. Thus the conjugated porphyrin dimer is the most promising core structure for PDT applications via multiphoton excitation.

Författare

M. K. Kuimova

Imperial College London

Markus Hoffmann

University of Oxford

Mikael Winters

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Mattias P Eng

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

M. Balaz

University of Oxford

I. P. Clark

Rutherford Appleton Laboratory

H. A. Collins

University of Oxford

S. M. Tavender

Rutherford Appleton Laboratory

C. J. Wilson

University of Oxford

Bo Albinsson

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Harry L. Anderson

University of Oxford

A. W. Parker

Rutherford Appleton Laboratory

D. Phillips

Imperial College London

Photochemical and Photobiological Sciences

1474-905X (ISSN) 1474-9092 (eISSN)

Vol. 6 6 675-682

Ämneskategorier

Kemi

DOI

10.1039/b700557a