Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families
Artikel i vetenskaplig tidskrift, 2008

The first genome-wide association study performed in a UK coeliac disease (CD) case-control cohort revealed association with a linkage disequilibrium block containing the KIAA1109/Tenr/IL2/IL21 genes. Also recently, an association with a non-synonymous polymorphism in Fcitalic gammaRIIa (CD32a) was reported in CD with an unusually strong P-value. We aimed to replicate the reported associations with the single nucleotide polymorphisms rs13119723 A>G and rs6822844 G>T in the KIAA1109/Tenr/IL2/IL21 region and rs1801274 G>A in the Fcitalic gammaRIIa gene in a family sample consisting of 325 Swedish/Norwegian families using the robust transmission disequilibrium test. The family sample used in this study included 100 families with two or more children affected by CD and 225 families with one affected child. We could confirm significant association between the polymorphisms rs13119723 A>G and rs6822844 G>T located in the KIAA1109/Tenr/IL2/IL21 region and CD (P-value 0.001 and 0.002, respectively). However, we found no association with the Fcitalic gammaRIIa rs1801274 G>A polymorphism (P-value=0.3). In conclusion, our results support the KIAA1109/Tenr/IL2/IL21 region as a true CD susceptibility region.

celiac

4q27

IL2

IL21

autoimmunity

FcRIIa

Författare

Svetlana Adamovic

Göteborgs universitet

silja amundsen

Universitetet i Oslo

Benedicte A Lie

Rikshospitalet-Radiumhospitalet HF

Audur Gudjonsdottir

Queen Silvia Children's Hospital

Henry Ascher

Nordiska Hogskolan for folkhalsovetenskap

Queen Silvia Children's Hospital

Johan Ek

Sykehuset Buskerud HF

David A van Heel

Queen Mary University of London

Staffan Nilsson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

Ludvig M Sollid

Rikshospitalet-Radiumhospitalet HF

Universitetet i Oslo

Åsa Torinsson Naluai

Göteborgs universitet

Genes and Immunity

1466-4879 (ISSN) 1476-5470 (eISSN)

Vol. 9 364-367

Ämneskategorier

Cell- och molekylärbiologi

DOI

10.1038/gene.2008.27