The development of an asymmetric Nicholas reaction using chiral phosphoramidite ligands
Artikel i vetenskaplig tidskrift, 2008

An asymmetric version of the Nicholas reaction involving the use of chiral phosphoramidite ligands has been developed. Treatment of a cobalt carbonyl complexed propargylic alcohol with two equivalents of the chiral ligand, followed by reaction with a silyl enol ether in the presence of a Lewis acid, afforded, after decomplexation, the desired product in up to 74% ee for the carbon-carbon bond forming step. © Georg Thieme Verlag Stuttgart.


N. Ljungdahl

Chalmers University of Technology

N. P. Pera

Chalmers University of Technology

K. H. O. Andersson

Chalmers University of Technology

Nina Kann

Chalmers, Kemi- och bioteknik, Organisk kemi


0936-5214 (ISSN) 1437-2096 (eISSN)

3 394-398