Expected Gene Order Distances and Model Selection in Bacteria
Artikel i vetenskaplig tidskrift, 2008
Motivation: The evolutionary distance inferred from gene-order
comparisons of related bacteria is dependent on the model.
Therefore, it is highly important to establish reliable assumptions
before inferring its magnitude.
Results: We investigate the patterns of dotplots between species
of bacteria with the purpose of model selection in gene-order
problems. We find several categories of data which can be explained
by carefully weighing the contributions of reversals, transpositions,
symmetrical reversals, single gene transpositions and single gene
reversals. We also derive method of moments distance estimates for
some previously uncomputed cases, such as symmetrical reversals,
single gene reversals and their combinations, as well as the single
gene transpositions edit distance.
method of moments estimate
gene order rearrangement