Oxygen radical production in leukocytes and disease severity in multiple sclerosis.
Artikel i vetenskaplig tidskrift, 2009

This study investigated the relationship between the formation of NADPH oxidase-dependent oxygen radicals in peripheral blood leukocytes ('respiratory burst') and disease severity in patients with multiple sclerosis (MS). Oxygen radical production was induced by formyl-Met-Leu-Phe (fMLF), Trp-Lys-Tyr-Met-Val-Met-NH2 (WKYMVM) or phorbol myristate acetate (PMA) and was assessed by quantifying superoxide anion, i.e. the initial radical formed by the NADPH oxidase. Disease severity was evaluated using the Multiple Sclerosis Severity Score (MSSS). In patients with severe disease, the production of superoxide anion was significantly lower for all three inducers of radical formation (p=0.04-0.004). Our findings are supportive of a protective role of oxygen radicals in autoimmunity.

Severity

immunology

Reactive Oxygen Species

Immunology

immunology

Multiple Sclerosis

Phagocytes

Respiratory Burst

NADPH Oxidase

Leukocytes

Författare

Natalia Mossberg

Göteborgs universitet

Charlotta Movitz

Göteborgs universitet

Kristoffer Hellstrand

Göteborgs universitet

Tomas Bergström

Göteborgs universitet

Staffan Nilsson

Chalmers, Matematiska vetenskaper, matematisk statistik

Göteborgs universitet

Oluf Andersen

Göteborgs universitet

Journal of neuroimmunology

1872-8421 (ISSN)

Vol. 213 1-2 131-134

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

DOI

10.1016/j.jneuroim.2009.05.013

PubMed

19589606

Mer information

Skapat

2017-10-07