Platform for Controlled Supramolecular Nano-Assembly
Artikel i vetenskaplig tidskrift, 2009

We here present a two-dimensional (2D) micro/nano-fluidic technique where reactant-doped liquid−crystal films spread and mix on micro- and nanopatterned substrates. Surface-supported phospholipid monolayers are individually doped with complementary DNA molecules which hybridize when these lipid films mix. Using lipid films to convey reactants reduces the dimensionality of traditional 3D chemistry to 2D, and possibly to 1D by confining the lipid film to nanometer-sized lanes. The hybridization event was observed by FRET using single-molecule-sensitive confocal fluorescence detection. We could successfully detect hybridization in lipid streams on 250 nm wide lanes. Our results show that the number and density of reactants as well as sequence of reactant addition can be controlled within confined liquid crystal films, providing a platform for nanochemistry with potential for kinetic control.

Författare

Ilja Czolkos

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Jonas Hannestad

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Aldo Jesorka

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

R. Kumar

University of Southampton

T. Brown

University of Southampton

Bo Albinsson

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Owe Orwar

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Nano Letters

1530-6984 (ISSN) 1530-6992 (eISSN)

Vol. 9 6 2482-2486

Ämneskategorier

Fysikalisk kemi

Atom- och molekylfysik och optik

DOI

10.1021/nl901254f