Multiple sclerosis incidence in the era of measles-mumps-rubella mass vaccinations.
Artikel i vetenskaplig tidskrift, 2009

BACKGROUND: Viral childhood infections may be involved in the multiple sclerosis (MS) pathogenesis. Following national Swedish vaccination programs, measles sharply declined in the 1970s, and measles, mumps, and rubella were virtually eliminated in cohorts born from 1981. OBJECTIVES: To examine whether the vaccination induced reduction in these infections influences the MS incidence. In addition, the public health aspect justified an early evaluation of beneficial as well as harmful effects of mass vaccinations. MATERIALS AND METHODS: From an incidence material of 534 MS patients, born 1959-1990, we selected one unvaccinated cohort and four cohorts, each corresponding to a vaccination program (MS patients = 251). RESULTS: With the ability to detect a decrease by 30-35%, and an increase by 37-48% in the MS incidence in the first three cohorts, we found no vaccination related MS incidence changes. The background MS incidence showed a significant gradual age dependent increase. CONCLUSIONS: While the present follow-up provided limited power in the last cohort, there is no evidence as yet that the radical decline in three viral infections influenced the MS incidence. However, the increasing background MS incidence of unknown cause may have concealed a reduction in MS risk associated with mass vaccinations.

epidemiology

epidemiology

Measles

Multiple Sclerosis

Sweden

epidemiology

Proportional Hazards Models

therapeutic use

prevention & control

Sex Distribution

Risk Reduction Behavior

epidemiology

Measles-Mumps-Rubella Vaccine

Age Distribution

epidemiology

prevention & control

Cohort Studies

Incidence

Comorbidity

Mumps

Rubella

prevention & control

adverse effects

Författare

Cecilia Ahlgren

Göteborgs universitet

Anders Odén

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

Kjell Torén

Göteborgs universitet

Oluf Andersen

Göteborgs universitet

Acta Neurologica Scandinavica

0001-6314 (ISSN) 1600-0404 (eISSN)

Vol. 119 5 313-20

Ämneskategorier

Fysiologi

DOI

10.1111/j.1600-0404.2008.01131.x

PubMed

19154535

Mer information

Skapat

2017-10-07