Exploring the role of phosphorus substituents on the enantioselectivity of Ru-catalysed ketone hydrogenation using tridentate phosphine-diamine ligands
Artikel i vetenskaplig tidskrift, 2011
Methods to produce a range of new phosphine-diamine ligands from phosphino-aldehydes have been developed and a hypothesis that larger P-substituents would increase the enantioselectivity towards the (S) isomer in Ru-catalysed ketone hydrogenation of acetophenone has been examined; the successful validation of this hypothesis is further evidence that the mechanism of these catalysts involves a secondary amine assisted reduction.
hybrid ligands
asymmetric hydrogenation
aromatic ketones
alkylation
imines
proline
ruthenium hydride complexes
aminophosphine ligands
rhodium
design
Författare
S. D. Phillips
University of St Andrews
Kristian Andersson
Chalmers, Kemi- och bioteknik, Organisk kemi
Nina Kann
Chalmers, Kemi- och bioteknik, Organisk kemi
M. T. Kuntz
Washington and Lee University
M. B. France
Washington and Lee University
P. Wawrzyniak
University of St Andrews
M. L. Clarke
University of St Andrews
Catalysis Science and Technology
2044-4753 (ISSN) 2044-4761 (eISSN)
Vol. 1 8 1336-1339Ämneskategorier
Kemi
DOI
10.1039/c1cy00253h