A high-performance lab-on-a-chip liquid sensor employing surface acoustic wave resonance: part II
Artikel i vetenskaplig tidskrift, 2019

We recently introduced an in-liquid sensing concept based on surface acoustic resonance (SAR) in a lab-on-a-chip resonant device with one electrical port. The 185 MHz one-port SAR sensor has a sensitivity comparable to other surface acoustic wave (SAW) in-liquid sensors, while offering a high quality factor (Q) in water, low impedance, and fairly low susceptibility to viscous damping. In this work, we present significant design and performance enhancements of the original sensor presented in part I. A novel 'lateral energy confinement' (LEC) design is introduced, where the spatially varying reflectivity of the SAW reflectors enables strong SAW localization inside the sensing domain at resonance. An improvement in mass-sensitivity greater than 100% at resonance is achieved, while the measurement noise stays below 0.5 ppm. Sensing performance was evaluated through real-time measurements of the binding of 40 nm neutravidin-coated SiO2nanoparticles to a biotin-labeled lipid bilayer. Two complementary sensing parameters are studied, the shift of resonance frequency and the shift of conductance magnitude at resonance.


surface acoustic wave





Kiryl Kustanovich

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Ventsislav Mitkov Yanchev

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Astrid Olivefors

Student vid Chalmers

Baharan Ali Doosti

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Tatsiana Lobovkina

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Aldo Jesorka

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Journal of Micromechanics and Microengineering

0960-1317 (ISSN) 13616439 (eISSN)

Vol. 29 2 024001

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Stiftelsen för Strategisk forskning (SSF) (SBE13-0125), 2014-06-01 -- 2020-12-31.

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Reservoir Computing with Real-time Data for future IT (RECORD-IT)

Europeiska kommissionen (EU) (EC/H2020/664786), 2015-09-01 -- 2018-08-31.


Innovation och entreprenörskap


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