Artificial intelligence-aided CT segmentation for body composition analysis: a validation study
Artikel i vetenskaplig tidskrift, 2021

Background: Body composition is associated with survival outcome in oncological patients, but it is not routinely calculated. Manual segmentation of subcutaneous adipose tissue (SAT) and muscle is time-consuming and therefore limited to a single CT slice. Our goal was to develop an artificial-intelligence (AI)-based method for automated quantification of three-dimensional SAT and muscle volumes from CT images. Methods: Ethical approvals from Gothenburg and Lund Universities were obtained. Convolutional neural networks were trained to segment SAT and muscle using manual segmentations on CT images from a training group of 50 patients. The method was applied to a separate test group of 74 cancer patients, who had two CT studies each with a median interval between the studies of 3 days. Manual segmentations in a single CT slice were used for comparison. The accuracy was measured as overlap between the automated and manual segmentations. Results: The accuracy of the AI method was 0.96 for SAT and 0.94 for muscle. The average differences in volumes were significantly lower than the corresponding differences in areas in a single CT slice: 1.8% versus 5.0% (p < 0.001) for SAT and 1.9% versus 3.9% (p < 0.001) for muscle. The 95% confidence intervals for predicted volumes in an individual subject from the corresponding single CT slice areas were in the order of ± 20%. Conclusions: The AI-based tool for quantification of SAT and muscle volumes showed high accuracy and reproducibility and provided a body composition analysis that is more relevant than manual analysis of a single CT slice.


Neural networks (computer)

Body composition

Subcutaneous fat

Tomography (x-ray



Pablo Borrelli

Sahlgrenska universitetssjukhuset

R. Kaboteh

Sahlgrenska universitetssjukhuset

Olof Enqvist

Eigenvision AB

Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik

Johannes Ulén

E. Tragardh

Skånes universitetssjukhus (SUS)

Henrik Kjölhede

Göteborgs universitet

Sahlgrenska universitetssjukhuset

L. Edenbrandt

Sahlgrenska universitetssjukhuset

Göteborgs universitet

European Radiology Experimental

25099280 (eISSN)

Vol. 5 1 11


Annan medicinteknik

Radiologi och bildbehandling

Medicinsk bildbehandling





Mer information

Senast uppdaterat