Ranjeet Kumar

Senior Research Engineer at Chemical Biology

Ranjeet Kumar works as a Senior research engineer in the research group of Pernilla Wittung Stafshede at Chemical Biology. Ranjeet is involved in developing schemes, strategies, methods for purification and analysis of different proteins. He is supporting and working closely with different researchers on various projects. His research is focused on understanding the molecular events involved in protein folding/misfolding and disease manifestation. His interests lie in the area of metal and small molecule interaction with proteins and their functional repercussions in neurodegeneration, cancer and copper homeostasis. He manages the Protein production platform at the division.

Source: chalmers.se
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Showing 17 publications

2024

Copper ion incorporation in α-synuclein amyloids

Gulshan Rameshrao Walke, Ranjeet Kumar, Pernilla Wittung Stafshede
Protein Science. Vol. 33 (4)
Journal article
2023

Amyloids of α-Synuclein Promote Chemical Transformations of Neuronal Cell Metabolites

Istvan Horvath, Khadra A. Mohamed, Ranjeet Kumar et al
International Journal of Molecular Sciences. Vol. 24 (16)
Journal article
2022

Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro

Xiaolu Zhang, Gulshan Rameshrao Walke, Istvan Horvath et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 119 (37), p. e2206905119-
Journal article
2021

C-terminal truncation of α-synuclein alters DNA structure from extension to compaction

Kai Jiang, Sandra Rocha, Ranjeet Kumar et al
Biochemical and Biophysical Research Communications. Vol. 568, p. 43-47
Journal article
2021

Macromolecular crowding modulates α-synuclein amyloid fiber growth

Istvan Horvath, Ranjeet Kumar, Pernilla Wittung Stafshede
Biophysical Journal. Vol. 120 (16), p. 3374-3381
Journal article
2021

Effects of the toxic metals arsenite and cadmium on α-synuclein aggregation in vitro and in cells

Emma Lorentzon, Istvan Horvath, Ranjeet Kumar et al
International Journal of Molecular Sciences. Vol. 22 (21)
Journal article
2021

Orientation of α-Synuclein at Negatively Charged Lipid Vesicles: Linear Dichroism Reveals Time-Dependent Changes in Helix Binding Mode

Sandra Rocha, Ranjeet Kumar, Bengt Nordén et al
Journal of the American Chemical Society. Vol. 143 (45), p. 18899-18906
Journal article
2021

Production of functional human fetal hemoglobin in Nicotiana benthamiana for development of hemoglobin-based oxygen carriers

Selvaraju Kanagarajan, Magnus L.R. Carlsson, Sandeep Chakane et al
International Journal of Biological Macromolecules. Vol. 184, p. 955-966
Journal article
2020

Differential effects of Cu2+ and Fe3+ ions on in vitro amyloid formation of biologically-relevant α-synuclein variants

Emma Lorentzon, Ranjeet Kumar, Istvan Horvath et al
Biometals. Vol. 33 (2-3), p. 97-106
Journal article
2020

Correlation between Cellular Uptake and Cytotoxicity of Fragmented α-Synuclein Amyloid Fibrils Suggests Intracellular Basis for Toxicity

Xiaolu Zhang, Emelie Vilhelmsson Wesén, Ranjeet Kumar et al
ACS Chemical Neuroscience. Vol. 11 (3), p. 233-241
Journal article
2020

Graphene oxide sheets and quantum dots inhibit alpha-synuclein amyloid formation by different mechanisms

Marziyeh Ghaeidamini, David Bernson, Nima Sasanian et al
Nanoscale. Vol. 12 (37), p. 19450-19460
Journal article
2019

Wilson disease missense mutations in ATP7B affect metal-binding domain structural dynamics

Kumaravel Ponnandai Schanmugavel, Ranjeet Kumar, Yaozong Li et al
Biometals. Vol. 32 (6), p. 875-885
Journal article
2019

Synaptic vesicle mimics affect the aggregation of wild-type and A53T α-synuclein variants differently albeit similar membrane affinity

Sandra Rocha, Ranjeet Kumar, Istvan Horvath et al
Protein engineering, design & selection : PEDS. Vol. 32 (2), p. 59-66
Journal article
2019

Interaction between Copper Chaperone Atox1 and Parkinson's Disease Protein α-Synuclein Includes Metal-Binding Sites and Occurs in Living Cells

Istvan Horvath, Stephanie Blockhuys, Darius Šulskis et al
ACS Chemical Neuroscience. Vol. 10 (11), p. 4659-4668
Journal article
2018

Abundant fish protein inhibits α-synuclein amyloid formation

Tony Werner, Ranjeet Kumar, Istvan Horvath et al
Scientific Reports. Vol. 8 (1)
Journal article
2018

Copper chaperone blocks amyloid formation via ternary complex

Istvan Horvath, Tony Werner, Ranjeet Kumar et al
Quarterly Reviews of Biophysics. Vol. 51, p. e6-e6
Journal article
2017

Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics

Ranjeet Kumar, Candan Ariöz, Yaozong Li et al
Biometals. Vol. 30 (1), p. 27-35
Journal article

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