Development of efficient xylose fermenting and acid-tolerant yeast strains - a crucial step towards commercial (scale) cellulose-based fuel production!

Research Project, 2012 – 2015

The aim of this project is to develop new yeast strains suitable for a feasible large-scale lignocellulose based bioethanol production process. The project is part of a interdisciplinary project cluster, involving LTH and SEKAB. Xylose fermentation will be improved through a blend of metabolic engineering and randomized techniques, while acetic acid tolerance will be increased with the combination of two entirely novel strategies involving cell membrane modification and direct conversion of acetic acid to added value products. Finally, efficient xylose fermenting and acid-tolerant yeast strains will be developed by combining the results in an industrial strain background. Their fermentation capacity will be mapped. The strength of the project is a unique combination of state-of –the-art facilities, competences and experience in the field, within a interdisciplinary project cluster, which will lead towards strains directly applicable to commercial scale cellulose based fuel production.

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