Towards robust and efficient xylose fermentation of lignocellulose into ethanol

The efficient conversion of both glucose and xylose in the presence of lignocellulose-derived inhibitors is one of the main factors required for a cost-effective lignocellulosic bioethanol production. The development of robust, xylose-fermenting microorganisms is therefore a crucial aspect towards reaching such a goal. In a previous project, we successfully isolated, characterized and sequenced the genome of the natural xylose-fermenting yeast Candida intermedia. Our results reveal an enriched xylose utilizing system (number of transporters and enzymes related to the pathway) that allows C. intermedia to assimilate xylose with faster rates than other related species. In the present project, we will further investigate C. intermedia with the aim of elucidating the complete metabolic and physiological mechanisms that enable its fast xylose assimilation. Further, these features will be incorporated into Saccharomyces cerevisiae to improve xylose uptake and fermentation rates.

Participants

Cecilia Geijer (contact)

Forskare vid Chalmers, Biology and Biological Engineering, Industrial Biotechnology

Fábio Luis Da Silva Faria Oliveira

Doktor vid Chalmers, Biology and Biological Engineering, Industrial Biotechnology

David Moreno

Forskare vid Chalmers, Biology and Biological Engineering, Industrial Biotechnology

Lisbeth Olsson

Professor vid Chalmers, Biology and Biological Engineering, Industrial Biotechnology

Funding

Swedish Energy Agency

Funding Chalmers participation during 2016–2017

Related Areas of Advance and Infrastructure

Sustainable development

Driving Forces

Energy

Areas of Advance

Life Science Engineering

Areas of Advance

More information

Latest update

2017-02-06