Towards robust and efficient xylose fermentation of lignocellulose into ethanol
Research Project, 2016
– 2017
The efficient conversion of both glucose and xylose in the presence of lignocellulose-derived inhibitors is one of the main factors required for a cost-effective lignocellulosic bioethanol production. The development of robust, xylose-fermenting microorganisms is therefore a crucial aspect towards reaching such a goal. In a previous project, we successfully isolated, characterized and sequenced the genome of the natural xylose-fermenting yeast Candida intermedia. Our results reveal an enriched xylose utilizing system (number of transporters and enzymes related to the pathway) that allows C. intermedia to assimilate xylose with faster rates than other related species. In the present project, we will further investigate C. intermedia with the aim of elucidating the complete metabolic and physiological mechanisms that enable its fast xylose assimilation. Further, these features will be incorporated into Saccharomyces cerevisiae to improve xylose uptake and fermentation rates.
Participants
Cecilia Geijer (contact)
Chalmers, Life Sciences, Industrial Biotechnology
Fábio Luis Da Silva Faria Oliveira
Chalmers, Life Sciences, Industrial Biotechnology
David Moreno
Chalmers, Life Sciences, Industrial Biotechnology
Lisbeth Olsson
Chalmers, Life Sciences, Industrial Biotechnology
Funding
Swedish Energy Agency
Project ID: 2015-007020
Funding Chalmers participation during 2016–2017
Related Areas of Advance and Infrastructure
Sustainable development
Driving Forces
Energy
Areas of Advance
Life Science Engineering (2010-2018)
Areas of Advance