CRISPRi technology for fine-tuned stress response in yeast
Research Project , 2018 – 2019

In this project, we will use the cutting-edge CRISPRi technology, for developing robust industrial yeast strains for the production of bioethanol and other biofuels- and chemicals. Using the CRISPRi technology we will elucidate the stress responses of yeast. This knowledge can be used for engineering novel production strains. Robust, stress-tolerant yeast for the cost-effective production of renewable energy carriers are needed for reaching Sweden’s targets for a fossil-free fleet by 2030. Today, the main challenge for making biofuels and chemicals from lignocellulosic biomass, made from residues from agriculture and forestry, is the presence of inhibitors that are toxic for the cells and cause severe stress that lower the productivity.

Participants

Vaskar Mukherjee (contact)

Doktor vid Chalmers, Biology and Biological Engineering, Industrial Biotechnology

Yvonne Nygård

Forskarassistent vid Chalmers, Biology and Biological Engineering, Industrial Biotechnology

Collaborations

Stanford University

Stanford, USA

University of Gothenburg

Gothenburg, Sweden

Funding

Chalmers Area of Advance Energy

Funding Chalmers participation during 2018–2019

The Royal Swedish Academy of Science

Funding Chalmers participation during 2018–2019

Stiftelsen Wilhelm och Martina Lundgrens Vetenskapsfond

Funding Chalmers participation during 2018–2019

Related Areas of Advance and Infrastructure

Energy

Areas of Advance

More information

Latest update

2018-09-11